Results 251 to 260 of about 3,232,072 (306)
FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source
Data from Functional Analysis of Rare <i>RAS</i> Variants of Unknown Significance
Soohwan Park +6 more
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Functional analysis of glaucoma data
Statistics in Medicine, 2013We refer glaucoma to a category of eye disorders often associated with a dangerous buildup of intraocular pressure (IOP), which can damage the eyes’ optic nerve that transmits visual information to the brain. Because IOP changes over time, it is a function of time, and it is an advantage that we analyze the phenomenon using functional data analysis. In
Hosseini-Nasab, Mohammad +1 more
openaire +3 more sources
2001
Most statistical analyses involve one or more observations taken on each of a number of individuals in a sample, with the aim of making inferences about the general population from which the sample is drawn. In an increasing number of fields, these observations are curves or images.
Silverman, BW, Ramsay, JO
openaire +1 more source
Most statistical analyses involve one or more observations taken on each of a number of individuals in a sample, with the aim of making inferences about the general population from which the sample is drawn. In an increasing number of fields, these observations are curves or images.
Silverman, BW, Ramsay, JO
openaire +1 more source
Functional Analysis of Metabolomics Data
2016Metabolomics aims at characterizing the repertory of small chemical compounds in a biological sample. As it becomes more massive and larger sets of compounds are detected, a functional analysis is required to convert these raw lists of compounds into biological knowledge.
Mónica, Chagoyen +2 more
openaire +2 more sources
2006
In many different fields of applied statistics the object of interest is depending on some continuous parameter, i.e. continuous time. Typical examples in biostatistics are growth curves or temperature measurements. Although for technical reasons, we are able to measure temperature just in discrete intervals — it is clear that temperature is a ...
openaire +1 more source
In many different fields of applied statistics the object of interest is depending on some continuous parameter, i.e. continuous time. Typical examples in biostatistics are growth curves or temperature measurements. Although for technical reasons, we are able to measure temperature just in discrete intervals — it is clear that temperature is a ...
openaire +1 more source