Results 141 to 150 of about 65,551 (301)
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
On Some Dependencies between Functional Forms in Functional Programming Systems [PDF]
, 1981 In the present paper, some dependencies between functional forms in functional programming systems are demonstrated. It is shown that any functional form can be expressed by using only the forms composition, condition and ...
Radenski, Atanas
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Fuzzy Functional Dependencies as a Method of Choice for Fusion of AIS and OTHR Data. [PDF]
Sensors (Basel), 2019 Mohamed Mostafa MAR +4 more
europepmc +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Sound and decidable type inference for functional dependencies [PDF]
, 2004 . Functional dependencies are a popular and useful extension to Haskell style type classes. In this paper, we give a reformulation of functional dependencies in terms of Constraint Handling Rules (CHRs).
Peter J. Stuckey +2 more
core
P444: IDENTIFICATION OF FUNCTIONAL GENETIC DEPENDENCIES IN CEBPA-MUTATED ACUTE MYELOID LEUKEMIA
HemaSphere, 2022 L. Proietti +6 more
doaj +1 more source
Computing Optimal Repairs for Functional Dependencies. [PDF]
Proc ACM SIGACT SIGMOD SIGART Symp Princ Database Syst, 2018 Livshits E, Kimelfeld B, Roy S.
europepmc +1 more source