Results 201 to 210 of about 57,558 (262)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Rethink context engineering using an attention-based architecture. [PDF]

Sci Rep
Yin Y.
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

RA-BiMENet: Continuous-Time 4D Medical Image Interpolation via Relation-Aware Bi-Directional Motion Estimation. [PDF]

Sensors (Basel)
Li L, Lyu J.
europepmc   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Hyperbolic Kernel Graph Neural Networks for Neurocognitive Decline Analysis From Multimodal Brain Imaging. [PDF]

IEEE Trans Pattern Anal Mach Intell
Yang M, Sun Y, Wang Q, Bozoki A, Kohi M, Liu M.   +5 more
europepmc   +1 more source

Exploring physical and functional EEG connectivity with multilayer graph transformer convolutional networks for emotion recognition. [PDF]

Front Hum Neurosci
Rahman SMA, Khalil MI, Zhou H, Ding Z, Guo Y.   +4 more
europepmc   +1 more source

Application of transformer models in medical image segmentation: a narrative review. [PDF]

Quant Imaging Med Surg
Xu Y, Peng Y, Zhang C, Jiang K, She X, Feng L.   +5 more
europepmc   +1 more source

STAR-GO: improving protein function prediction by learning to hierarchically integrate ontology-informed semantic embeddings. [PDF]

Bioinformatics
Akça ME, Uludoğan G, Özgür A, Baytaş İM.   +3 more
europepmc   +1 more source

Multi-feature fusion for gene prediction and functional peptide identification. [PDF]

Front Microbiol
Ma C, Wei Q, Wang G, Miao Y, Yuan L.
europepmc   +1 more source