Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
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SpaLSTF: Diffusion-based generative model with BiLSTM and XCA-Transformer for spatial transcriptomics imputation. [PDF]
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Incremental Discovery of Imprecise Functional Dependencies
ACM Journal of Data and Information Quality, 2020Functional dependencies (fds) are one of the metadata used to assess data quality and to perform data cleaning operations. However, to pursue robustness with respect to data errors, it has been necessary to devise imprecise versions of functional ...
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This work proposes a method for identifying functional dependencies among components of complex technical infrastructures using databases of alarm messages. The developed method is based on the representation of the alarm database by a binary matrix, the
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Knowledge discovery from databases copes with several problems including the heterogeneity of data and interpreting the solution in an understandable and convenient form for domain experts.
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