Results 131 to 140 of about 683,225 (336)

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

open access: yesFEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr   +5 more
wiley   +1 more source

Teaching Python with team‐based learning: using cloud‐based notebooks for interactive coding education

open access: yesFEBS Open Bio, EarlyView.
This study presents a novel approach to teaching Python and bioinformatics using team‐based learning and cloud‐hosted notebooks. By integrating interactive coding into biomedical education, the method improves accessibility, student engagement, and confidence—especially for those without a computing background.
Nuno S. Osório, Leonardo D. Garma
wiley   +1 more source

A functional equation method for ordinary differential equations

open access: yesJournal of Mathematical Analysis and Applications, 1970
is a function of class C oO and every locally integrable solution f of this equat ion is equal almost everywhere to a solution of class Coo. II. Suppose that 1 ° q~i( t )sC 4 in an open interval A c R, i= 1, ..., m, 2 ° there exists an c~A such that ~oi(~) = 0 for i = 1 .. . . , m, a v d f t a . d f . 3 ° the vectors ~oi = ~oi (~) and ~oi =~oi (~) ( i=
openaire   +4 more sources

Menthol‐like cooling compounds, including (R)‐(‐)‐carvone, inhibit the human bitter taste receptors for saccharin and acesulfame K

open access: yesFEBS Open Bio, EarlyView.
We report that some menthol‐like cooling compounds, including (R)‐(‐)‐carvone, act as inhibitors of TAS2R31 and TAS2R43, which are taste receptors responsible for the intrinsic bitter aftertastes of saccharin and acesulfame K. However, there was little correlation between the intensity of the cooling sensation and the potency of bitterness inhibition ...
Miyuu Saito, Takumi Misaka
wiley   +1 more source

Holomorphic solutions to linear first-order functional differential equations

open access: yesElectronic Journal of Differential Equations, 2005
In this paper we study holomorphic solutions to linear first-order functional differential equations that have a nonlinear functional argument. We focus on the existence of local solutions at a fixed point of the functional argument and the holomorphic ...
Bruce van Brunt, Jonathan C. Marshall
doaj  

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