Results 101 to 110 of about 672,782 (279)

Semiconcavity of the Minimum Time Function for Differential Inclusions

, 2012
In this paper we consider the Minimum Time Problem with dynamics given by a differential inclusion. We prove that the minimum time function is semiconcave under suitable hypotheses on the multifunction F.
CANNARSA, PIERMARCO, Marino, F, Wolenski, P.   +2 more
openaire   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Existence results for neutral functional differential and integrodifferential inclusions in Banach spaces

Electronic Journal of Differential Equations, 2000
In this paper we investigate the existence of solutions on a compact interval for the first and second order initial-value problems for neutral functional differential and integrodifferential inclusions in Banach spaces.
Mouffak Benchohra, Sotiris K. Ntouyas
doaj  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Functional Random Differential Inclusions with Memory

Journal of Research in Applied Mathematics
In this paper, we discuss the neutral functional random differential inclusions defined on a separable Banach space and depending in a measurable way on a random parameter. We prove an existence result for a class of neutral functional random differential inclusions with memory and establish a condition under which the existence of viable solutions ...
B. K. Pedge B. K. Pedge, D.S. Palimkar D.S. Palimkar   +1 more
openaire   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Existence results for functional differential inclusions

Electronic Journal of Differential Equations, 2001
In this note we investigate the existence of solutions to functional differential inclusions on compact intervals. We use the fixed point theorem introduced by Covitz and Nadler for contraction multi-valued maps.
Mouffak Benchohra, Sotiris K. Ntouyas
openaire   +4 more sources

Formation of β-cyclodextrin inclusion complexes with a series of structurally related parabens: Preparation, physicochemical characterization and antifungal properties

Carbohydrate Polymer Technologies and Applications
In β-cyclodextrin (β-CD) complexation, the structure of the guest compound critically influences the physicochemical properties and bioactivities of the resulting materials.
Wenwen Zhang, Tai-Ping Zhou, Wenjing Zou, Yuyu Wang, Kexuan Wang, Yichao Yang, Chuan Liu, Zhuochao Tu, Qingqing Liu, Yongjun Yuan   +9 more
doaj   +1 more source