Results 81 to 90 of about 67,156 (272)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Initial value problems for fractional functional differential inclusions with Hadamard type derivatives in Banach spaces [PDF]

open access: yesSurveys in Mathematics and its Applications, 2018
The authors establish sufficient conditions for the existence of solutions to boundary value problems for fractional differential inclusions involving the Hadamard type derivatives of order α ∈ (0,1] in Banach spaces.
John R. Graef   +2 more
doaj  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Existence of mild solutions of second-order neutral functional differential inclusions with nonlocal conditions in Banach spaces

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 2004
We study the existence of mild solutions of the nonlinear second-order neutral functional differential and integrodifferential inclusions with nonlocal conditions in Banach spaces.
S. Marshal Anthoni   +2 more
doaj   +1 more source

On more general boundary value problems involving sequential fractional derivatives

open access: yesAdvances in Difference Equations, 2019
We investigate the existence of solutions for new boundary value problems of Caputo-type sequential fractional differential equations and inclusions supplemented with nonlocal integro-multipoint boundary conditions.
Bashir Ahmad   +3 more
doaj   +1 more source

" Existence of solutions for a class of functional differential inclusions with ""maxima""" [PDF]

open access: yesFixed Point Theory, 2018
This paper is mainly concerned with a boundary value problem associated to a second-order differential inclusion with ``maxima'' term. Based upon suitable fixed point theorems combined with selection theorems, some existence results are established when the multi-valued nonlinear term has convex or non convex values.
openaire   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

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