Results 241 to 250 of about 796,111 (314)

The impact of physical and mind exercise on functional disability in activities of daily living among the oldest old. [PDF]

BMC Public Health
Wang S, Wu Z, Guo Z, Wang F, Liu B.
europepmc   +1 more source

Single‐Cell Atlas of Subchondral Bone Marrow Lesions Reveals Proteostasis Dysfunction as a Druggable Mechanism for Early Osteoarthritis

Advanced Science, EarlyView.
This study reveals that abnormal mechanical stress downregulates the expression of HSP70 and impairs proteasome function in osteoarthritic bone cells, leading to misfolded collagen I accumulation and ER stress. When intracellular proteostasis capacity is exceeded, USP19 mediates the secretion of misfolded proteins into the extracellular space ...
Hailun Xu, Ting He, Yu Qian, Jia Li, Bowei Ni, Xiaojie Xu, Huanbo Wang, Peng Wang, Guoqing Cao, Siqi Ying, Guangyu Ding, Rong Wang, Zenghui Gu, Wei Li, Zhentao Man, Houfeng Zheng, Zhaohua Zhu, Zhen Li, Qingjun Meng, Chao Zheng, Liu Yang   +20 more
wiley   +1 more source

Prevalence and factors associated with functional disability in daily activities among older adults in Bisha, Saudi Arabia: A cross-sectional study. [PDF]

Saudi Med J
Alhalafi AH, Eljack IA, Almalki SM, Doghish AS, Mohammed OA, Alhalafi AF, Alqahtani SM, Alqahtani HS, Abdalla GM, Jibo AM.   +9 more
europepmc   +1 more source

Mechanical Overloading‐Induced Nanomineral Crystal Perturbation from the Osteochondral Interface: A Potential Initiator of Osteoarthritis

Advanced Science, EarlyView.
Laser‐induced graphene (LIG) provides a scalable, laser‐direct‐written route to porous graphene architecture with tunable chemistry and defect density. Through heterojunction engineering, catalytic functionalization, and intrinsic self‐heating, LIG achieves highly sensitive and selective detection of NOX, NH3, H2, and humidity, supporting next ...
Nan Jiang, Rong Ren, Zhan Su, Jiahao Zhou, Pinyin Cao, Sicheng Zhang, Zhen Li, Chao Li, Songsong Zhu   +8 more
wiley   +1 more source

Principal Component Analysis of Stair Negotiation and Floor Transition Kinematics in Older Adults With and Without Functional Disability: Cross-Sectional Study. [PDF]

JMIR Aging
Moreira J, Teles IDS, Cunha B, Félix J, Guedes DC, Alves LAT, Santos R, Sousa ASP.   +7 more
europepmc   +1 more source

Pulsed electromagnetic field therapy versus sham therapy as an adjunct to conventional physiotherapy on pain, functional disability, and quality of life in patients undergoing total hip arthroplasty: a randomized placebo controlled trial protocol. [PDF]

Trials
Gharjare A, Deshmukh M.
europepmc   +1 more source

Associations between Functional Disability and Chronic Conditions with Depressive Symptoms in Vietnamese-Origin Older Refugees. [PDF]

Health Soc Work
Miyawaki CE, Garcia JM, Medina LD, Nguyen KN, Meyer OL, Markides KS.   +5 more
europepmc   +1 more source