Results 201 to 210 of about 5,240 (291)

Unraveling the Interplay Between Collaborative Governance and Experimentation for Transformative Potential in Circular Water Systems: A Dutch Case Study

open access: yesEnvironmental Policy and Governance, EarlyView.
ABSTRACT Freshwater availability is a critical climate change challenge in coastal delta regions. This challenge requires a transformative change toward circular water management. While experimentation and collaborative governance are recognized as enablers of transformative change, their interaction remains complex and insufficiently understood ...
Flavia Simona Albu Cosoveanu   +3 more
wiley   +1 more source

SLE 38: Formal, Functional and Typological Perspectives on Discourse and Grammar

open access: yesCírculo de Lingüística Aplicada a la Comunicación, 2023
Círculo de Lingüística Aplicada a la Comunicación
doaj  

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

open access: yesESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia   +2 more
wiley   +1 more source

Effects of fenfluramine and sigma‐1‐dependent pharmacological and genetic modulation in a mouse kindling model

open access: yesEpilepsia, EarlyView.
Abstract Objective Sigma‐1 is a chaperone protein that serves as a key homeostatic regulator, implicated in neuronal excitability and seizure control. Positive allosteric modulators offer a use‐dependent means to enhance Sigma‐1 activity, potentially with favorable tolerability compared to direct agonists.
Eva‐Lotta von Rüden   +5 more
wiley   +1 more source

Leptin Reduces Running in a Rodent Anorexia Nervosa Model via a Distributed Neural Network

open access: yesEuropean Eating Disorders Review, EarlyView.
ABSTRACT Objective Hyperactivity is a persistent and clinically relevant symptom in anorexia nervosa (AN). Hyperactivity is inversely correlated with leptin levels. While systemic leptin administration attenuates hyperactivity in rodent models, the specific brain regions mediating this effect remain unclear.
Nick J. M. Papavoine   +6 more
wiley   +1 more source

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