Results 71 to 80 of about 1,111,420 (338)

A transient inflammatory response contributes to oxaliplatin neurotoxicity in mice

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1985-1998, December 2022., 2022
Abstract Objectives Peripheral neuropathy is a relevant dose‐limiting adverse event that can affect up to 90% of oncologic patients with colorectal cancer receiving oxaliplatin treatment. The severity of neurotoxicity often leads to dose reduction or even premature cessation of chemotherapy.
Aina Calls, Abel Torres‐Espin, Marc Tormo, Laura Martínez‐Escardó, Núria Bonet, Ferran Casals, Xavier Navarro, Víctor J. Yuste, Esther Udina, Jordi Bruna   +9 more
wiley   +1 more source

Functional equations and martingales [PDF]

arXiv, 2019
We consider functional equations (Cauchy's, Abel's and some other functional equations) and show that to find general solution of these equations is equivalent to establish that a space-transformation of a Brownian Motion by suitable function (or functions) is a martingale.
arxiv  

Targeted metabolomics reveals novel diagnostic biomarkers for colorectal cancer

Molecular Oncology, EarlyView.
This study employed targeted metabolomic profiling to identify 302 distinct metabolites present in platelet‐rich plasma (PRP), revealing aberrant metabolic profiles amongst individuals diagnosed with colorectal cancer (CRC). Compared to carcinoembryonic antigen (CEA) and cancer antigen 19‐9 (CA199), our metabolite panel showed improved sensitivity ...
Zuojian Hu, Fenglin Shen, Yang Liu, Ziqing Zhong, Yongling Chen, Zhiyuan Xia, Cuiju Mo, Hongxiu Yu   +7 more
wiley   +1 more source

The anterior nucleus of the thalamus plays a role in the epileptic network

Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 2010-2024, December 2022., 2022
Abstract Objectives We investigated both the metabolic differences and interictal/ictal discharges of the anterior nucleus of the thalamus (ANT) in patients with epilepsy to clarify the relationship between the ANT and the epileptic network. Methods Nineteen patients with drug‐resistant epilepsy who underwent stereoelectroencephalography were studied ...
Hao Yan, Xueyuan Wang, Tao Yu, Duanyu Ni, Liang Qiao, Xiaohua Zhang, Cuiping Xu, Wei Shu, Yuping Wang, Liankun Ren   +9 more
wiley   +1 more source

A Functional Equation in Arithmetic [PDF]

Transactions of the American Mathematical Society, 1936
which occurs in all theories of numerical functions hitherto considered. The two most highly developed theories of this kind are those in which multiplication in the ring of all numerical functions is abstractly identical with C (Cauchy) or D (Dirichlet) multiplication of infinite series.t Lehmer's five postulates are sufficient for the development of ...
openaire   +2 more sources

KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells

Molecular Oncology, EarlyView.
We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock, Lina Benzien, Sandra Lange, Maja Huehns, Alexandra Runge, Catrin Roolf, Anett Sekora, Gudrun Knuebel, Hugo Murua Escobar, Christian Junghanss, Anna Richter   +10 more
wiley   +1 more source

Chains of fundamental mutually homogeneous functions with a common real eigenvalue

St. Petersburg Polytechnical University Journal: Physics and Mathematics, 2020
This work continues the study of the properties of mutually homogeneous functions, which are a generalization of Euler homogeneous functions and can be used in the synthesis of electric and magnetic fields of electron and ion-optical systems with special
Berdnikov Alexander, Solovyev Konstantin, Krasnova Nadezhda   +2 more
doaj   +1 more source

Green's function for Poisson's equation and the EEG equation with Neumann boundary condition on $n$-balls [PDF]

arXiv, 2019
We provide an elementary derivation of the Green's function for Poisson's equation with Neumann boundary data on balls of arbitrary dimension, which was recently found in [Sadybekov et al., Eurasian Math. J. 7(2):100-105, 2016]. The underlying idea consists of first computing the Green's function for the electroencephalography (EEG) equation (Poisson's
arxiv  

Functional equations with extrema

Journal of Mathematical Analysis and Applications, 1978
in which p and q are known functions, and u is the unknown function, originate from multistage control processes of discrete type (see [I, 21). Bellman [3] showed that if p(.z, U) =: X* + vz and q(x, n) x + an, then the functional equation has a unique solution u(x) = cxz (for some constant c) in a class of functions which pass through the origin, and ...
T Howroyd, T Howroyd, J.E Maxfield, J.E Maxfield   +3 more
openaire   +2 more sources

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

Molecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin, Audrey Vinchent, Marie Fernandes, Isabelle Damour, Agathe Laratte, Rémi Tellier, Gabriella O. Estevam, Jean‐Pascal Meneboo, Céline Villenet, Clotilde Descarpentries, James S. Fraser, Martin Figeac, Alexis B. Cortot, Etienne Rouleau, David Tulasne   +14 more
wiley   +1 more source