Results 41 to 50 of about 257,218 (311)

Therapeutic Apheresis for Intravenous Methylprednisolone‐Refractory Neuromyelitis Optica Spectrum Disorder: Clinical and Radiological Outcomes in a Single‐Center Case Series

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi, Daisuke Katagiri, Takeyuki Watadani, Shunichi Matsuda, Hiroshi Kaneko, Noritoshi Arai   +5 more
wiley   +1 more source

Absence of xenotropic murine leukaemia virus-related virus in UK patients with chronic fatigue syndrome [PDF]

, 2010
Background: Detection of a retrovirus, xenotropic murine leukaemia virus-related virus (XMRV), has recently been reported in 67% of patients with chronic fatigue syndrome. We have studied a total of 170 samples from chronic fatigue syndrome patients from
Kerr Jonathan R, Breuer, J, Groom, HC, Randal Edward, Makinson, Kerry, Frank M Mattes, Baptista, Sarah, Kerr, JR, Groom, Harriet C.T., Bishop Kate N, Boucherit, VC, Kate N Bishop, Gow, John W., Gow, JW, Stoye Jonathan P, Judith Breuer, Baptista, S, Virginie C Boucherit, Kerry Makinson, Randal, Edward, Groom Harriet CT, Gow John W, Makinson Kerry, Hagan Suzanne, Groom, HCT, Makinson, K, Bishop, KN, Baptista Sarah, Suzanne Hagan, Harriet CT Groom, John W Gow, Boucherit, Virginie C., Edward Randal, Breuer Judith, Boucherit Virginie C, Randal, E, Hagan, S, Jonathan R Kerr, Mattes, Frank M., Hagan, Suzanne; id_orcid, Stoye, JP, Mattes Frank M, Sarah Baptista, Jonathan P Stoye, Mattes, FM   +44 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Effect of mental fatigue on induced tremor in human knee extensors

, 2014
In this study, the effects of mental fatigue on mechanically induced tremor at both a low (3-6Hz) and high (8-12Hz) frequency were investigated. The two distinct tremor frequencies were evoked using two springs of different stiffness, during 20s ...
Budini, Francesco, Durbaba R., de Vito, Giuseppe, Lowery M., De Vito G., Lowery, Madeleine, Durbaba, Rade, Budini F.   +7 more
core   +1 more source

Functional Near-Infrared Spectroscopy-Based Evidence of the Cerebral Oxygenation and Network Characteristics of Upper Limb Fatigue

Bioengineering, 2023
Objective: The objective of this research is to better understand the effects of upper limb fatigue on the cerebral cortex. The aim of this study was to investigate the characteristics of cerebral oxygenation and cortical functional connectivity in ...
Feng Li, Jiawei Bi, Zhiqiang Liang, Lu Li, Yu Liu, Lingyan Huang   +5 more
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Metabolic Mechanisms of Vocal Fatigue [PDF]

, 2013
Vocal fatigue is among the most debilitating conditions affecting individuals with voice disorders. Impressions about mechanisms potentially underlying vocal fatigue have varied depending on how fatigue is defined, participants studied, and measures made,
Nanjundeswaran, Chayadevie
core  

Pragmatic intervention for increasing self-directed exercise behaviour and improving important health outcomes in people with multiple sclerosis: a randomised controlled trial [PDF]

, 2014
Background - Exercise programmes that can demonstrate evidence of long-lasting clinical effectiveness are needed for people with multiple sclerosis (PwMS).
L Humphreys, Woodroofe, Nicola, N Snowdon, Tosh, J., Saxton, J., Petty, Jane, J Petty, Saxton, John, Daley, A., B Sharrack, Carter, Anouska, Roalfe, A., Petty, J., N Woodroofe, Sharrack, B., Humphreys, Liam, Humphreys, L., A Roalfe, Snowdon, Nicky, Daley, Amanda, J Tosh, A Carter, A Daley, Roalfe, Andrea, Tosh, Jonathan, Sharrack, Basil, JM Saxton   +26 more
core   +1 more source

Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler, Vivian Maas, Arian Taheri Amin, Jennifer Faber, Tamara Schaprian, Katharina Hill, Matthis Synofzik, Lisa H. Graf, Heike Jacobi, Manuela Lima, Ana F. Ferreira, Bart P. van de Warrenburg, Ilse H. J. Willemse, Dagmar Timmann, Andreas Thieme, Paola Giunti, Hector Garcia‐Moreno, Magda M. Santana, Jeannette Hübener‐Schmid, Elin H. Davies, Thomas Klockgether   +20 more
wiley   +1 more source