Results 91 to 100 of about 573,448 (262)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Ultrahigh piezoelectricity and temperature stability in piezoceramics by synergistic design

Nature Communications
Piezoceramics with both high piezoelectric properties and broad temperature usage range are highly in demand for sensor and actuator applications. Unfortunately, the trade-off relationship between two properties poses a significant challenge that remains
Wenbin Liu, Ting Zheng, Zhangyang Zhou, Yi Ding, Yue Qin, Zhengqian Fu, Xuezheng Ruan, Zhipeng Gao, Xiang Lv, Jiagang Wu   +9 more
doaj   +1 more source

Bio-hydrogelated structured sensors of high-performances for degradable bioelectronics

Materials & Design
Compared with state-of-the-art polymeric counterparts, proteinic self-assemblies may bridge the gap between device performances and biocompatibility/biodegradability requirement, showing promising potentials in implantable bioelectronic scenarios ...
Kang Ma, Hao Lyu, Jinhe Wang, Yunxiao Wang, Haoran Wu, Dandan Dai, Shihang Wang, Ruiqi Liu, Yancheng Wang, Dingyi Pan, Deqing Mei, Chengchen Guo, Kai Tao   +12 more
doaj   +1 more source

Understanding the Effects of In-Service Temperature and Functional Fluid on the Ageing of Silicone Rubber. [PDF]

Polymers (Basel), 2019
Kashi S, De Souza M, Al-Assafi S, Varley R.   +3 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Long-term cognitive training enhances fluid cognition and brain connectivity in individuals with MCI

Translational Psychiatry
Amnestic mild cognitive impairment (aMCI) is a risk factor for Alzheimer’s disease (AD). Multi-domain cognitive training (CT) may slow cognitive decline and delay AD onset.
Elveda Gozdas, Bárbara Avelar-Pereira, Hannah Fingerhut, Lauren Dacorro, Booil Jo, Leanne Williams, Ruth O’Hara, S. M. Hadi Hosseini   +7 more
doaj   +1 more source

Negative impact of very mild volume overload on the heart function in patients on chronic hemodialysis

Renal Failure
Objectives Heart failure is associated with higher mortality of hemodialysis patients. Fluid overload is a major risk factor for cardiovascular disease in these patients, but it is frequently clinically silent.
Kristyna Michalickova, Jan Malik, Anna Valerianova, Zdenka Hruskova, Vladimira Bednarova, Frantisek Lopot, Kristina Buryskova Salajova, Zuzana Hladinova, Tereza Vychodilova, Satu Sinikka Pesickova, Katarina Rocinova, Monika Tothova, Barbora Szonowska, Marketa Kratochvilova, Lucie Kaiserova, Simona Janakova, Vladimir Tesar   +16 more
doaj   +1 more source

Novel multi-functional fluid flow device for studying cellular mechanotransduction. [PDF]

J Biomech, 2016
Lyons JS, Iyer SR, Lovering RM, Ward CW, Stains JP.   +4 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source