Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Functional Renormalization-Group Analysis of Luttinger Liquids with Impurities
, 2006 Sabine Andergassen
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Tuning the HOMO Energy of the Triarylamine Molecules with Orthogonal HOMO and LUMO Using Functional Groups [PDF]
, 2023 Junpeng Zhuang +5 more
openalex +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Detection, Isolation, and Functional Studies of Mouse Pulmonary Group 2 Innate Lymphoid Cells
, 2022 Allyssa Strohm, Taylor A. Doherty
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Cyanine Masking: A Strategy to Test Functional Group Effects on Antibody Conjugate Targeting [PDF]
, 2022 Ek Raj Thapaliya +6 more
openalex +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Bimetallic NiCo Nanoparticles Embedded in Organic Group Functionalized Mesoporous Silica for Efficient Hydrogen Production from Ammonia Borane Hydrolysis [PDF]
Juti Rani Deka +5 more
openalex +1 more source
Numerical calculation of the functional renormalization group fixed-point functions at the depinning transition [PDF]
, 2007 Alberto Rosso +2 more
openalex +1 more source