E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Niche Differentiation Characteristics of Phytoplankton Functional Groups in Arid Regions of Northwest China Based on Machine Learning. [PDF]
Yun L +7 more
europepmc +1 more source
The effect of hydroxyl functional groups and molar mass on the viscosity of non-crystalline organic and organic–water particles [PDF]
James W. Grayson +11 more
openalex +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Developmental Toxicity of Photolithography-Relevant Per- and Polyfluoroalkyl Substances (PFAS) Reveals Concerns for Less-Studied Functional Groups. [PDF]
Cao Y +7 more
europepmc +1 more source
On additive and isotone functionals on ordered groups [Lecture]
František Šik
openalex +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Laser-Induced Covalent Defunctionalization of Graphene - Precise Patterning and Site-Selective Removal of Functional Groups. [PDF]
Nagel T, Gerein K, Hauke F, Hirsch A.
europepmc +1 more source

