Results 131 to 140 of about 107,051 (305)
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Identities for the Ramanujan zeta function
We prove formulas for special values of the Ramanujan tau zeta function. Our formulas show that $L(Δ, k)$ is a period in the sense of Kontsevich and Zagier when $k\ge12$. As an illustration, we reduce $L(Δ, k)$ to explicit integrals of hypergeometric and algebraic functions when $k\in\{12,13,14,15\}$.
openaire +3 more sources
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Identities are not only constructed through coherent and unified stories about significant events but also formed within the interactions during everyday social encounters.
Narushima, Miya +3 more
core +1 more source
Design and analysis strategies for robust microbiome ageing research
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Functional Identities of Degree Two
Let \(R\) be a prime ring with extended centroid \(C\). A functional identity of degree two for \(R\) is an expression \(\sum^n_{i=1} F_i (y) xa_i+\sum^m_{i=1} G_i (x) yb_i+\sum^k_{i=1} c_i yH_i(x)+\sum^s_{i=1} d_i xK_i(y)\) which yields zero for all \(x, y \in R\), where all \(a_i, b_i, c_i, d_i \in R\), and all \(F_i\), \(G_i\), \(H_i\), \(K_i\) are ...
openaire +1 more source
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Inflationary non-Gaussianities in alpha vacua and consistency with conformal symmetries
We study the conformal invariance of inflationary non-Gaussianities associated with scalar fluctuations in a non-Bunch-Davies initial state, known as the α-vacuum, in single-field slow-roll inflation.
Arhum Ansari +4 more
doaj +1 more source
An identity for matrix functions [PDF]
openaire +2 more sources
Reconstructing enzyme evolution by protein engineering
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source

