Results 51 to 60 of about 101,884 (265)
Rebelling for a reason: protein structural "outliers". [PDF]
PLoS ONE, 2013 Analysis of structural variation in domain superfamilies can reveal constraints in protein evolution which aids protein structure prediction and classification. Structure-based sequence alignment of distantly related proteins, organized in PASS2 database,
Gandhimathi Arumugam +3 more
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
ParticlesWe present a pedagogical and self-contained account of the functional formulation of non-Abelian gauge theories, aimed at the construction of a process-independent effective charge for Yang–Mills theory.
Daniele Binosi
doaj +1 more source
SuperTracer: a calculator of functional supertraces for one-loop EFT matching
Journal of High Energy Physics, 2021 We present SuperTracer, a Mathematica package aimed at facilitating the functional matching procedure for generic UV models. This package automates the most tedious parts of one-loop functional matching computations.
Javier Fuentes-Martín +4 more
doaj +1 more source
Is Identity a Functional Property?
, 2015 Ruth Marcus defended the absolute notion of identity, in particular through her theorem aboutthe necessity of identity. Critics of absolute identity have attempted to relativise the notion, withno great success. I here consider another possible view : functionalism about identity, the view ,similar to one proposed about truth, that identity could be a ...
openaire +2 more sources
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Cellular Taxonomy of the Mouse Striatum as Revealed by Single-Cell RNA-Seq
Cell Reports, 2016 The striatum contributes to many cognitive processes and disorders, but its cell types are incompletely characterized. We show that microfluidic and FACS-based single-cell RNA sequencing of mouse striatum provides a well-resolved classification of ...
Ozgun Gokce +9 more
doaj +1 more source
Generation of human islet cell type-specific identity genesets
Nature Communications, 2022 Generation of surrogate cells with stable functional identities is crucial for developing cell-based therapies. Efforts to produce insulin-secreting replacement cells to treat diabetes require reliable tools to assess islet cellular identity.
Léon van Gurp +9 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source