Results 111 to 120 of about 549,143 (266)
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
T<sub>H</sub>17 cells require ongoing classic IL-6 receptor signaling to retain transcriptional and functional identity. [PDF]
Sci Immunol, 2020 Harbour SN +9 more
europepmc +1 more source
Functional Identities of Degree Two
Journal of Algebra, 1995 Let \(R\) be a prime ring with extended centroid \(C\). A functional identity of degree two for \(R\) is an expression \(\sum^n_{i=1} F_i (y) xa_i+\sum^m_{i=1} G_i (x) yb_i+\sum^k_{i=1} c_i yH_i(x)+\sum^s_{i=1} d_i xK_i(y)\) which yields zero for all \(x, y \in R\), where all \(a_i, b_i, c_i, d_i \in R\), and all \(F_i\), \(G_i\), \(H_i\), \(K_i\) are ...
openaire +1 more source
Role reversal of functional identity in host factors: Dissecting features affecting pro-viral versus antiviral functions of cellular DEAD-box helicases in tombusvirus replication. [PDF]
PLoS Pathog, 2020 Wu CY, Nagy PD.
europepmc +1 more source
An identity for matrix functions [PDF]
Pacific Journal of Mathematics, 1974 openaire +2 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Presenting a hybrid model for measuring place identity in urban spaces (Case study: Tehran\'s historical district) [PDF]
تحقیقات کاربردی علوم جغرافیاییAccording to the fact that place identity is influenced by various social, physical, semantic, functional, and natural factors, each of these dimensions has multiple indicators with complex internal relationships; Measuring and evaluating it is a ...
Mana Taheri +3 more
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