Results 201 to 210 of about 5,039,714 (254)

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Functional Identities

Frontiers in Mathematics, 2007
various constructions and concrete examples of d-free sets are given, and FIćs on d-free sets are thoroughly studied. Part III deals with applications. Its main purpose is to demonstrate how one can find FI's when considering different problems, and then effectively use the general theory exposed in Part II. Perhaps the most illuminating example of the
Matej Brešar
exaly   +3 more sources

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Identities for Multiplicative Functions

Canadian Mathematical Bulletin, 1967
Throughout this paper the arithmetic functions L(n) and w(n) denote respectively the number and product of the distinct prime divisors of the integer n > 1, with L(1) = 0 and w(1) = 1. Also letWe recall that an arithmetic function f(n) is said to be multiplicative if f(1) = 1 and f(mn) = f(m)f(n) whenever (m, n) = 1, where (m, n) denotes as usual ...
Subbarao, M. V., Gioia, A. A.
openaire   +1 more source

COMBINATORIAL IDENTITIES AND HYPERGEOMETRIC FUNCTIONS

Rocky Mountain Journal of Mathematics, 2022
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Alzer, Horst, Richards, Kendall C.
openaire   +1 more source

Wigner Function for Identical Particles

Journal of Computational Electronics, 2004
In this work the Wigner function approach to quantum transport developed for the single electron case is extended to a more complicated system for n indistingushable particles. In particular we study how the Monte Carlo tecnique and the Wigner paths method can be applyed to a single particle Wigner function defined for a system of n interacting ...
E. Cancellieri, BORDONE, Paolo, A. Bertoni, G. Ferrari, JACOBONI, Carlo   +4 more
openaire   +1 more source