Results 81 to 90 of about 5,039,714 (254)

Identity Development in Adulthood : Introduction

open access: yes, 2016
In line with Erikson’s suggestions, increasing empirical evidence substantiates that considerable identity development takes place over the course of adulthood. What then does identity development during adulthood entail?
Kroger, Jane, Fadjukoff, Päivi
core   +1 more source

I am Me: Brain systems integrate and segregate to establish a multidimensional sense of self

open access: yesNeuroImage, 2020
Humans experience a sense of self, which is proposed to emerge from the integration of intrinsic and extrinsic self-processing through the propagation of information across brain systems.
Simone Di Plinio   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Physiological normoxia and absence of EGF is required for the long-term propagation of anterior neural precursors from human pluripotent cells.

open access: yesPLoS ONE, 2014
Widespread use of human pluripotent stem cells (hPSCs) to study neuronal physiology and function is hindered by the ongoing need for specialist expertise in converting hPSCs to neural precursor cells (NPCs).
Bilada Bilican   +8 more
doaj   +1 more source

The microbiome in human skin aging

open access: yesFEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana   +3 more
wiley   +1 more source

The extended self, functional constancy, and personal identity [PDF]

open access: yes, 2013
Personal indexicals are often taken to refer to the agent of an expression’s context, but deviant uses (e.g. ‘I’m parked out back’) complicate matters. I argue that personal indexicals refer to the extended self of the agent, where the extended self is a
Fost, Joshua
core   +2 more sources

’n Reformatoriese perspektief op sin en identiteit

open access: yesKoers : Bulletin for Christian Scholarship, 1993
This article addresses the ultimate question regarding meaning and the closely related problem of identity from a reformational vantage point. Although the human being’s central or religious identity can be distinguished from his various functional ...
Magda van Niekerk
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

A unimodality identity for a Schur function

open access: yesJournal of Combinatorial Theory, Series A, 1992
A new formula for the principal specialization of a Schur function is given. The identity implies that the sequence of coefficients of this polynomial is unimodal. The proof of the main result is based on a combinatorial construction due to \textit{S. V. Kerov}, \textit{A. N. Kirillov} and \textit{N. Yu. Reshetikhin} [J. Sov. Math. 41, No. 2, 916--924 (
Frederick M. Goodman   +2 more
openaire   +2 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

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