Results 91 to 100 of about 2,065,342 (284)

Functional delta residuals and applications to functional effect sizes

, 2020
Given a functional central limit (fCLT) and a parameter transformation, we use the functional delta method to construct random processes, called functional delta residuals, which asymptotically have the same covariance structure as the transformed limit ...
Davenport, Samuel, Schwartzman, Armin, Telschow, Fabian J. E.   +2 more
core  

High-veracity functional imaging in scanning probe microscopy via Graph-Bootstrapping

Nature Communications, 2018
Scanning probe microscopy methods can generate high-dimensional data sets that correspond to a low-dimensional sample. Here, Li et al. develop a graphical bootstrapping method to quantitatively visualize large-scale high-dimensional datasets.
Xin Li, Liam Collins, Keisuke Miyazawa, Takeshi Fukuma, Stephen Jesse, Sergei V. Kalinin   +5 more
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Leftover Food as a Sustainable Source of Astaxanthin Through Fermentation Using Phaffia rhodozyma

Foods
Natural astaxanthin is a bioactive with high antioxidant power, widely suitable for many applications. This study explores the potential of leftover food as a sustainable and low-cost substrate for producing astaxanthin via direct fermentation using ...
Rossella Vadalà, Eleonora Di Salvo, Laura De Maria, Giovanna Lo Vecchio, Giovanni Bartolomeo, Rita De Pasquale, Claudia Genovese, Nicola Cicero, Rosaria Costa   +8 more
doaj   +1 more source

UV-activated ZnO films on a flexible substrate for room temperature O2 and H2O sensing

Scientific Reports, 2017
We demonstrate that UV-light activation of polycrystalline ZnO films on flexible polyimide (Kapton) substrates can be used to detect and differentiate between environmental changes in oxygen and water vapor.
Christopher B. Jacobs, Artem B. Maksov, Eric S. Muckley, Liam Collins, Masoud Mahjouri-Samani, Anton Ievlev, Christopher M. Rouleau, Ji-Won Moon, David E. Graham, Bobby G. Sumpter, Ilia N. Ivanov   +10 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

The analyses of structural covariance and structural covariance similarity of cortical morphological measures

NeuroImage
Structural covariance refers to the concurrent changes in one morphological measure between two brain regions. Structural covariance of cortical morphological measures such as cortical thickness (CT), surface area (SA), and cortical volume (CV) have been
Xi Zhang, Yanmin Peng, Dongyue Li, Ailin Hou, Meng Liang, Chunshui Yu   +5 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source