Results 101 to 110 of about 2,065,342 (284)

Hyperthyroidism in cats, part I : anatomy, physiology, pathophysiology, diagnosis and imaging [PDF]

, 2016
In the first part of this review article, thyroid anatomy, physiology and pathophysiology are reviewed to continue more specifically on hyperthyroidism, the most common thyroid disorder in cats.
Daminet, Sylvie, Peremans, Kathelijne, Saunders, Jimmy, Vandermeulen, Eva, Volckaert, Veerle   +4 more
core   +1 more source

Optimal Bayes Classifiers for Functional Data and Density Ratios

, 2016
Bayes classifiers for functional data pose a challenge. This is because probability density functions do not exist for functional data. As a consequence, the classical Bayes classifier using density quotients needs to be modified.
Dai, Xiongtao, Müller, Hans-Georg, Yao, Fang   +2 more
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Combination of volume and perfusion parameters reveals different types of grey matter changes in schizophrenia

Scientific Reports, 2017
Diverse brain structural and functional changes have been reported in schizophrenia. Identifying different types of brain changes may help to understand the neural mechanisms and to develop reliable biomarkers in schizophrenia.
Lixue Xu, Wen Qin, Chuanjun Zhuo, Huaigui Liu, Jiajia Zhu, Chunshui Yu   +5 more
doaj   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Maternal fluoxetine exposure alters cortical hemodynamic and calcium response of offspring to somatosensory stimuli [PDF]

, 2019
Epidemiological studies have found an increased incidence of neurodevelopmental disorders in populations prenatally exposed to selective serotonin reuptake inhibitors (SSRIs).
Brier, Lindsey M, Culver, Joseph P, Dougherty, Joseph D, Maloney, Susan E, Rahn, Rachel M   +4 more
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Current Density Impedance Imaging of an Anisotropic Conductivity in a Known Conformal Class [PDF]

, 2013
We present a procedure for recovering the conformal factor of an anisotropic conductivity matrix in a known conformal class in a domain in Euclidean space of dimension greater than or equal to 2.
Hoell, Nicholas, Moradifam, Amir, Nachman, Adrian   +2 more
core  

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

MRI-guided cell membrane-camouflaged bimetallic coordination nanoplatform for combined tumor phototherapy

Materials Today Bio
Nanotechnology for tumor diagnosis and optical therapy has attracted widespread interest due to its low toxicity and convenience but is severely limited due to uncontrollable tumor targeting.
Mengyang Zhou, Yifei Wang, Yaning Xia, Yinhua Li, Jianfeng Bao, Yong Zhang, Jingliang Cheng, Yupeng Shi   +7 more
doaj   +1 more source