Results 21 to 30 of about 10,648 (267)

jFuzzyLogic: a Java Library to Design Fuzzy Logic Controllers According to the Standard for Fuzzy Control Programming [PDF]

International Journal of Computational Intelligence Systems
Fuzzy Logic Controllers are a specific model of Fuzzy Rule Based Systems suitable for engineering applications for which classic control strategies do not achieve good results or for when it is too difficult to obtain a mathematical model.
Pablo Cingolani, Jesús Alcalá-Fdez
doaj   +1 more source

Effects Without Monads: Non-determinism – Back to the Meta Language [PDF]

Electronic Proceedings in Theoretical Computer Science, 2019
We reflect on programming with complicated effects, recalling an undeservingly forgotten alternative to monadic programming and checking to see how well it can actually work in modern functional languages. We adopt and argue the position of factoring an
Oleg Kiselyov
doaj   +1 more source

Binary addition in a living cell based on riboregulation. [PDF]

PLoS Genetics, 2018
Synthetic biology aims at (re-)programming living cells like computers to perform new functions for a variety of applications. Initial work rested on transcription factors, but regulatory RNAs have recently gained much attention due to their high ...
Arantxa Rosado, Teresa Cordero, Guillermo Rodrigo   +2 more
doaj   +1 more source

A Computational Workflow to Predict Biological Target Mutations: The Spike Glycoprotein Case Study

Molecules, 2023
The biological target identification process, a pivotal phase in the drug discovery workflow, becomes particularly challenging when mutations affect proteins’ mechanisms of action.
Pietro Cozzini, Federica Agosta, Greta Dolcetti, Alessandro Dal Palù   +3 more
doaj   +1 more source

Design and implementation of CoLoR architecture control plane based on P4

Dianxin kexue, 2018
P4 (programming protocol-independent packet processor) can redefine the fields recognized by the forwarding device and its processing logic through software programming.Aiming at the problems that the new architecture CoLoR faces in actual deployment and
Ruohan LIU, Hongbin LUO, Xingbeng WEN
doaj   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Methodology for Automated Design of Quantum-Dot Cellular Automata Circuits

IEEE Open Journal of Nanotechnology, 2023
Quantum-dot Cellular Automata (QCA) provide very high scale integration potential, very high switching frequency, and have extremely low power demands, which make the QCA technology quite attractive for the design and implementation of large-scale, high ...
Orestis Liolis, Vassilios A. Mardiris, Ioannis G. Karafyllidis, Sorin Cotofana, Georgios Ch. Sirakoulis   +4 more
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

A Scoping Review on Artificial Intelligence–Supported Interventions for Nonpharmacologic Management of Chronic Rheumatic Diseases

Arthritis Care &Research, EarlyView.
This review summarizes artificial intelligence (AI)‐supported nonpharmacological interventions for adults with chronic rheumatic diseases, detailing their components, purpose, and current evidence base. We searched Embase, PubMed, Cochrane, and Scopus databases for studies describing AI‐supported interventions for adults with chronic rheumatic diseases.
Nirali Shah, Alexis Castellanos, Yen Chen, John Piette, Amy Bucher, Susan Murphy   +5 more
wiley   +1 more source