Results 121 to 130 of about 6,916,372 (302)

Metabolic and Fluid Biomarkers Support Microglia Activation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Amyotrophic lateral sclerosis is an incurable neurodegenerative disease involving motor neuron degeneration and metabolic and immune dysfunction. We combined clinical data, cerebrospinal fluid biomarkers and fluorodeoxyglucose positron emission tomography with magnetic resonance imaging to investigate the role of reactive microglia in disease ...
Matteo Zanovello, Francesca Serani, Alen Bebeti, Federica Paredi, Giulia Quadrio, Andrea Fortuna, Giacomo Maria Minicuci, Elena Pegoraro, Annachiara Cagnin, Diego Cecchin, Gianni Sorarù   +10 more
wiley   +1 more source

Neurovascular coupling, cognition, and cardiac function in stroke-free atrial fibrillation

NeuroImage: Clinical
Objectives: Atrial fibrillation (AF) is linked to cognitive impairment even without overt stroke, potentially via neurovascular coupling (NVC) dysfunction.
Songhong Yue, Jintao Wang, Jiahao Yan, Wanjun Hu, Jun Wang, Yucheng Ding, Laiyang Ma, Pengfei Wang, Na Han, Yurong Ma, Jing Zhang   +10 more
doaj   +1 more source

Diffuse MRI Edema Predicts Relapse in Cerebral Amyloid Angiopathy–Related Inflammation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To identify MRI predictors of relapse and quantify relapse and mortality risk in cerebral amyloid angiopathy–related inflammation (CAA‐RI). A secondary objective was to assess the association between mycophenolate mofetil use and relapse risk. Methods We performed a retrospective cohort study of 36 patients with CAA‐RI treated at the
G. Abbas Kharal, Gowtham Yerneni, Kim J. Griffin, Nicolas Thompson, Ken Uchino, Irene Katzan, Dolora Wisco, Abeer Farrag, Jayashree Sundarajan, Andrew Russman, M. Shazam Hussain   +10 more
wiley   +1 more source

Early Clinical and Cerebrospinal Fluid Predictors of 1‐Year Recurrence in Autoimmune GFAP Astrocytopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune glial fibrillary acidic protein astrocytopathy (GFAP‐A) is an inflammatory central nervous system disorder with variable outcomes. Relapse occurs in a subset of patients, but early predictors remain unclear. We aimed to identify admission‐available features associated with 1‐year recurrence and develop an interpretable ...
Qingting Hong, Yuping Xiao, Yuhan Wu, Ziyuan Huang, Weishan Liang, Li Xiao, Yaqing Shu, Tingting Lu, Yanyu Chang, Wei Qiu, Yuge Wang   +10 more
wiley   +1 more source

Ofatumumab Therapy and Long‐Term Seizure Outcomes of Patients With Relapsing Anti‐NMDA Receptor Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective There is a lack of studies on seizure outcomes associated with ofatumumab therapy in patients for relapsing anti‐N‐methyl‐D‐aspartate (NMDA) receptor encephalitis. We aimed to evaluate long‐term seizure outcomes of ofatumumab therapy for relapsing anti‐NMDA receptor encephalitis.
Jian Wang, Mengjiao Li, Ping Kong
wiley   +1 more source

Imaging memory in temporal lobe epilepsy: predicting the effects of temporal lobe resection [PDF]

, 2010
Functional magnetic resonance imaging can demonstrate the functional anatomy of cognitive processes. In patients with refractory temporal lobe epilepsy, evaluation of preoperative verbal and visual memory function is important as anterior temporal lobe ...
Thompson, P. J., Samson, R. S., Yogarajah, M., Symms, M. R., Koepp, M. J., Powell, R. H. W., Duncan, J. S., Bonelli, S. B.   +7 more
core  

Dynamic Changes in Serum Glial Fibrillary Acidic Protein Levels Predicts Early Neurological Deterioration After Intravenous Thrombolysis in Minor Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Minor strokes may be associated with early neurological deterioration (END) and disabilities. The objective was to investigate the role of serum glial fibrillary acidic protein (GFAP) levels in predicting END. Methods Data originated from a multicenter cohort study conducted prospectively.
Jie Zhou, Yang Qu, Reziya Abuduxukuer, Peng Zhang, Ting Wang, Jian‐Hua Gao, De‐Wang Pan, Zhi‐Mei Yuan, Chun‐Ying Li, Li‐Ping Chen, Jin‐Hua Chen, Ji‐Liang Gu, An‐Ying Wang, Li‐Gang Jiang, Liang Liu, Yong‐Fei Jiang, Chun‐Fei Wang, Yan Jia, Hong Xin, Chun‐Li Jiang, Ying‐Bin Qi, Xue‐Feng Hu, Song Li, Hang Jin, Zhen‐Ni Guo, Yi Yang, on behalf of the Biomarkers of Brain Injury Investigator Study Group, Lijuan Wang, Ting Wang, Jianhua Gao, Dewang Pan, Zhimei Yuan, Chunying Li, Liping Chen, Jinhua Chen, Jiliang Gu, Anying Wang, Ligang Jiang, Liang Liu, Yongfei Jiang, Chunfei Wang, Yan Jia, Hong Xin, Chunli Jiang, Yingbin Qi, Xuefeng Hu   +45 more
wiley   +1 more source

Complementing Engel Classification: Postoperative Scalp EEG as an Objective Indicator in SEEG‐Guided Radiofrequency Thermocoagulation—A Seizure‐Onset Pattern‐Based Stratified Analysis—

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Stereoelectroencephalography‐guided radiofrequency thermocoagulation (SEEG‐RFTC) is a minimally invasive therapy for drug‐resistant focal epilepsy. However, the relationship between specific seizure‐onset patterns (SOPs), particularly low‐voltage fast activity (LVFA), and postoperative scalp EEG normalization remains inadequately ...
Yi‐qing Yang, Rui Zhang, Haiyan Ma, Lu Yang, Xuefeng Qu, Qiqi Chen, Yan Zhang   +6 more
wiley   +1 more source

Does intermittent theta burst stimulation change oscillatory activity in the targeted left dorsolateral prefrontal cortex? - a resting-state EEG study

Brain Stimulation, 2023
Armita Faghani Jadidi, Angela Mastropasqua, Domenico Voso, Mikkel Malling Beck, Leo Tomasevic, Hartwig Siebner   +5 more
doaj   +1 more source

Juvenile Huntington Disease With Cerebellar‐Predominant Atrophy Identified by Genome Sequencing

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Juvenile Huntington disease accounts for a small fraction of Huntington disease cases and is driven by the largest trinucleotide repeat expansions. We describe a 6‐year‐old boy with progressive global regression, generalized dystonia, and epilepsy, in whom serial imaging showed striking cerebellar‐predominant atrophy with an initially normal ...
Enrique Gonzalez Saez‐Diez, Amy Tam, Siofra Carty, Monica Ferrer Socorro, Kathryn Yang, Darius Ebrahimi‐Fakhari   +5 more
wiley   +1 more source