Results 211 to 220 of about 3,816,554 (298)

Preoperative functional connectivity and postoperative neuropathic pain in degenerative cervical myelopathy: An exploratory postoperative follow-up study using resting-state functional MRI. [PDF]

Brain Spine
Nakagawa T, Eto F, Asada T, Inomata K, Ogata Y, Sakashita K, Sunami T, Shimizu T, Okuwaki S, Gamada H, Miura K, Noguchi H, Funayama T, Koda M, Yamazaki M, Takahashi H.   +15 more
europepmc   +1 more source

A Second Pathogenic Protein, PolyGN2C‐iso2, Reveals a Dual‐Protein Pathology in Neuronal Intranuclear Inclusion Disease

Advanced Science, EarlyView.
This study reveals that NOTCH2NLC transcript variant 2 generates PolyGN2C‐iso2, an aggregating protein present within intranuclear inclusions of NIID patient tissues. A novel mouse model expressing PolyGN2C‐iso2 recapitulates white matter abnormalities and cognitive deficits, mechanistically linked to mitochondrial dysfunction. These findings support a
Kang Zhang, Wenhao Ma, Yi Zhou, Zhijie Wu, Pan Gao, Hongze Niu, Hongfei Tai, Tianyi Zhao, Zheyue Dong, Li Li, Yan Zhang, An Wang, Si Shen, Yueyang Li, Sifei Yu, Yan Peng, Wang Sheng, Xiaoyan Dong, Hua Pan, Kaibin Shi, Magdalena J. Koziol, Xiaobing Wu, Zaiqiang Zhang   +22 more
wiley   +1 more source

UltraFast Layer-Resolved Encoding (uFLARE) functional MRI deciphers bidirectional signaling from spontaneous activity. [PDF]

Nat Commun
Carvalho J, Fernandes FF, Valente M, Haak KV, Shemesh N.   +4 more
europepmc   +1 more source

In Situ Profiling of Nanoscale Strains Uncovers Mechano‐Architectural Predictors of Aging and Osteoarthritis Emergence

Advanced Science, EarlyView.
In situ mechanical loading of osteoarthritis‐prone murine knee joints reveals that spatial alterations in subchondral plate microarchitecture precede cartilage loss and promote a shift from coordinated epiphyseal strain dissipation in healthy joints to focal subchondral strain concentration in osteoarthritis‐prone joints.
Aikta Sharma, Lucinda A. E. Evans, Lucie E. Bourne, Jishizhan Chen, Alissa L. Parmenter, Joseph Brunet, Kamel Madi, Sebastian Marussi, Andrew A. Pitsillides, Peter D. Lee, Katherine A. Staines   +10 more
wiley   +1 more source

Role of task-based functional MRI in the assessment of sports-related concussion: a systematic review. [PDF]

Front Neurol
Mirza M, Ahmed Z.
europepmc   +1 more source

Targeting the KCNC3‐Dependent Anterior Insular‐Lateral Orbitofrontal Cortex Glutamatergic Circuit Attenuates Post‐Traumatic Anxiety

Advanced Science, EarlyView.
Frontal lobe traumatic brain injury is associated with hyperactivity of an insular–orbitofrontal circuit in both patients and mice. By combination of integrating functional imaging, cell‐type–specific circuit manipulation, single‐cell transcriptomics, and whole‐cell recordings, this work identifies the downregulation of the potassium channel KCNC3 in ...
Meng‐Ge Li, Xiao‐Bo Qian, Hai‐Long Zhang, Di Li, Ling Ji, Xin‐Chun Xu, Jia‐Sheng Ding, Li‐Jun Yin, Li Zhang, Guang‐Yin Xu, Rong Gao   +10 more
wiley   +1 more source

Mapping lung function in late-onset Pompe disease using label-free functional MRI. [PDF]

iScience
Tan L, Wagner AL, Heiss R, Bayerl N, Zschüntzsch J, Regensburger AP, Alves F, Türk M, Schmidt S, Grimm R, Vorgerd M, Schlaffke L, Vogt-Wolz H, Claßen M, Stoecklein B, Buehler A, Woelfle J, Uder M, Hahn A, Mensch A, Winterholler M, Trollmann R, Raming R, Knieling F.   +23 more
europepmc   +1 more source

Review of Gastrointestinal Capsule Robots: Materials, Actuation, Diagnostics, and Therapeutics

Advanced Science, EarlyView.
This review examines gastrointestinal capsule robots through a systems engineering lens, covering shell materials, actuation and localization strategies, diagnostic modalities, therapeutic interventions, and commercialization status. By mapping the complete technological chain from fabrication to clinical deployment, this work identifies critical gaps ...
Zengsheng Li, Zhongguo Ren, Yiliang Lin, Xianfeng Xia, Tianlong Li, Kai Fung Chan, Philip Wai Yan Chiu, Wei Peng Yong, Mengmeng Sun   +8 more
wiley   +1 more source

Clinical Application of Resting-State Functional MRI for Individualized Localization of Core Language Areas in Patients with Drug-Resistant Epilepsy: An Observational Study. [PDF]

Neuropsychiatr Dis Treat
Wang M, Cui X, Zhang Y, Wang R, Yan Y, Zhou L, Fan Z, Li W.   +7 more
europepmc   +1 more source