Results 111 to 120 of about 3,398,903 (291)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Observations on the function of the round window [PDF]
The Journal of Physiology, 1940 C S, Hallpike, P, Scott
openaire +2 more sources
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
A Data Centric Approach to the Design of Unknown Input Functional Observers
IEEE AccessFunctional observers have been extensively studied in classical model-based literature for estimating only a portion of the state without reconstructing the full state, thereby providing computational efficiency and flexibility.
Pankaj Vadhvani +2 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Fault Estimation for Semi-Markov Jump Neural Networks Based on the Extended State Method
Applied SciencesThis paper addresses fault estimation in discrete-time semi-Markov jump neural networks (s-MJNNs) under the Round-Robin protocol and proposes an innovative extended state observer-based approach. Unlike studies considering only constant transition rates,
Lihong Rong, Yuexin Pan, Zhimin Tong
doaj +1 more source
IFAC-PapersOnLineThis paper proposes a novel approach for designing functional observers for nonlinear systems, with linear error dynamics and assignable poles. Sufficient conditions for functional observability are first derived, leading to functional relationships between the Lie derivatives of the output to be estimated and the ones of the measured output. These are
openaire +2 more sources
Linear Algebra and its Applications, 2010 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
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Nonlinear Discrete Observer for Flexibility Compensation of Industrial Robots [PDF]
, 2014 This paper demonstrates the solutions of digital observer implementation for industrial applications. A nonlinear high-gain discrete observer is proposed to compensate the tracking error due to the flexibility of robot manipulators. The proposed discrete
ABBA, Gabriel +2 more
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