Results 111 to 120 of about 12,638,942 (268)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

The association between acute nutritional changes and prognosis in ischemic stroke patients

Frontiers in Nutrition
BackgroundNutritional status during the acute phase of ischemic stroke can change dynamically and may influence patient outcomes. However, the impact of short-term nutritional changes on prognosis remains unclear.
Zhuangzhuang Jiang, Meiyun Zhang, Jingjing Li, Xiaorong Lu, Xiaolan Wu, Yuan Fang, Liang Wang, Dongjuan Xu   +7 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

The impact of continued inpatient therapies on functional recovery and community discharge in patients with acquired brain injury

Frontiers in Rehabilitation Sciences
IntroductionInpatient rehabilitation (IRF) is beneficial for patients with acquired brain injuries (ABI), yet some require ongoing therapy at a skilled nursing facility (SNF).
Esha Patel, Aditya Dharani, Simon Gelman, Hayk Petrosyan, Hayk Petrosyan, Hayk Petrosyan, Kristen A. Harris, Kristen A. Harris   +7 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Robotic‐assisted restricted kinematic alignment in total knee arthroplasty: A multicenter retrospective assessment of coronal phenotypes and early postoperative outcomes

Journal of Experimental Orthopaedics
Purpose The Coronal Plane Alignment of the Knee (CPAK) classification enables phenotype‐based total knee arthroplasty (TKA), but its application in robotic‐assisted TKA (RATKA) remains underexplored. We aim to describe the distribution of CPAK phenotypes
Ravi Teja Rudraraju, Sanjay Bhalchandra Londhe, Ponnanna Karineravanda Machaiah, Supreet Bajwa, Kunal Aneja, Police Jayaram Reddy, Kanakanala Jangi Reddy, Dolly Singh   +7 more
doaj   +1 more source

The Impact of Time from Diagnosis to Operating Room on Functional Outcomes in Patients with Traumatic Brain Injury: A Retrospective Study

Neurotrauma Reports
This study compares the functional outcomes of post-traumatic neurosurgical patients who underwent surgery within 4 h of diagnosis with those who underwent surgery >4 h after diagnosis.
Cheewin Khawprapa, Sasithorn Khawprapa
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source