Results 231 to 240 of about 2,750,599 (310)

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Thrombus iodine-based perviousness is associated with recanalisation and functional outcomes in endovascular thrombectomy. [PDF]

Stroke Vasc Neurol
Tian C, Liu S, Fu L, Guo J, Cao C, Sun Y, Ren T, Wang H, Wang S, Luo L, Wang L, Wei M, Xia S, Jin S, Han T, Hao N.   +15 more
europepmc   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Meniscal repair versus resection: Integrating pain mediator profiles with functional outcomes in a comparative effectiveness study. [PDF]

Medicine (Baltimore)
Liu C, Li W.
europepmc   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Functional outcomes and toxicity following focal low-dose-rate brachytherapy for low-intermediate risk prostate cancer. [PDF]

BJUI Compass
Adhami M, Cheng J, Anderson E, Smyth L, Davey C, Nguyen T, O'Sullivan R, Ryan A, Lawrentschuk N, Grummet J, See A.   +10 more
europepmc   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Effectiveness of exercise prehabilitation before anterior cruciate ligament reconstruction on functional outcomes - a single-blinded randomized controlled trial. [PDF]

Sci Rep
Abel R, Niederer D, Glowa A, Hansen N, Wilke C, Offerhaus C.   +5 more
europepmc   +1 more source

A prospective study of intravenous iron effectiveness on quality of life and functional outcomes in patients with cancer. [PDF]

Sci Rep
Köseoğlu FD, Tuğral A, Akyol M.
europepmc   +1 more source