Results 51 to 60 of about 12,638,942 (268)

The impact of multisite pain on functional outcomes in older adults: biopsychosocial considerations

Journal of Pain Research, 2019
Multisite pain, or pain that occurs simultaneously at >1 anatomical site, is more prevalent than single-site pain. While multisite pain affects over half of older adults, it remains an understudied pain entity that may have important functional ...
Katie A. Butera, S. Roff, T. Buford, Y. Cruz-Almeida   +3 more
semanticscholar   +1 more source

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

Functional outcomes of upper eyelid blepharoplasty: A systematic review.

Journal of Plastic, Reconstructive & Aesthetic Surgery, 2019
OBJECTIVE Various functional outcomes after upper blepharoplasty are reported in the literature. We systematically reviewed the literature to assess the objective and subjective functional effects of upper blepharoplasty.
M. H. J. Hollander, M. Contini, J. Pott, A. Vissink, R. Schepers, J. Jansma   +5 more
semanticscholar   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Hemispherectomy in adults and adolescents: Seizure and functional outcomes in 47 patients

Epilepsia, 2019
To examine longitudinal seizure and functional outcomes after hemispherectomy in adults and adolescents.
R. McGovern, Ahsan N. Moosa, L. Jehi, R. Busch, Lisa Ferguson, Ajay Gupta, J. Gonzalez-Martinez, E. Wyllie, I. Najm, W. Bingaman   +9 more
semanticscholar   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Chondroitinase Improves Anatomical and Functional Outcomes After Primate Spinal Cord Injury

Nature Neuroscience, 2019
Inhibitory extracellular matrices form around mature neurons as perineuronal nets containing chondroitin sulfate proteoglycans that limit axonal sprouting after CNS injury.
E. Rosenzweig, E. Salegio, Justine J Liang, J. Weber, C. Weinholtz, J. Brock, R. Moseanko, Stephanie Hawbecker, R. Pender, Christina Cruzen, J. Iaci, A. Caggiano, A. Blight, Barbara Haenzi, J. Huie, L. Havton, Y. Nout-Lomas, J. Fawcett, Adam R Ferguson, M. Beattie, J. Bresnahan, M. Tuszynski   +21 more
semanticscholar   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Impact of bystander automated external defibrillator use on survival and functional outcomes in shockable observed public cardiac arrests

Circulation, 2018
Background: Survival following out-of-hospital cardiac arrest (OHCA) with shockable rhythms can be improved with early defibrillation. Although shockable OHCA accounts for only ≈25% of overall arrests, ≈60% of public OHCAs are shockable, offering the ...
Ross A. Pollack, Siobhan P. Brown, T. Rea, T. Aufderheide, D. Barbic, J. Buick, J. Christenson, A. Idris, Jamie Jasti, Michael Kampp, P. Kudenchuk, S. May, Marc D. Muhr, G. Nichol, J. Ornato, G. Sopko, C. Vaillancourt, L. Morrison, M. Weisfeldt   +18 more
semanticscholar   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source