Results 81 to 90 of about 2,750,599 (310)

The impact of stroke: are people with aphasia different to those without? [PDF]

, 2011
Purpose. Stroke rehabilitation programmes aim to improve functional outcomes and quality of life. This study explored long-term outcomes in a cohort of people admitted to two acute stroke units with stroke.
Brott T, Dalemans RJP, Enderby P, Goldberg DP, Hackett ML, Katerina Hilari, Wade DT   +6 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Functional and Radiological Outcome of Displaced Lateral End Clavicle Fractures Treated With Open Reduction and Endobutton Fixation

Journal of Orthopaedic Case Reports
Introduction: Displaced lateral end clavicle fractures are challenging injuries with a high risk of non-union and functional impairment when treated conservatively. Open reduction and endobutton fixation is a novel surgical technique that aims to provide
Sree Shangamithra, Prem Kumar Kothimbakkam, Sanjay Nallagounder Krishnasamy, Thirumal Ranganathan, Bharath Vadivel Kumar, Vijayashankar Murugesan   +5 more
doaj   +1 more source

Ordinal Probit Functional Regression Models with Application to Computer-Use Behavior in Rhesus Monkeys

, 2019
Research in functional regression has made great strides in expanding to non-Gaussian functional outcomes, however the exploration of ordinal functional outcomes remains limited.
Coull, Brent A., Gazes, Regina Paxton, Hampton, Robert R., Meyer, Mark J., Morris, Jeffrey S.   +4 more
core   +1 more source

Bright light therapy as part of a multicomponent management program improves sleep and functional outcomes in delirious older hospitalized adults. [PDF]

, 2013
ObjectiveDelirium is associated with poor outcomes following acute hospitalization. A specialized delirium management unit, the Geriatric Monitoring Unit (GMU), was established.
Ancoli-Israel, Sonia, Chong, Mei Sian, Tan, Keng Teng, Tay, Laura, Wong, Yoke Moi   +4 more
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Minimally Invasive Versus Open Spinal Fusion Surgery for Spondylolisthesis Treatment

Journal of Orthopaedic Case Reports
Background: In recent years, there has been a growing utilization of minimally invasive (MI) techniques, which provide the potential advantages of minimizing surgical stress, post-operative pain, and hospitalization duration.
Shahzad Waqas Munazzam, Vikramaditya Rai, Qazi Adam Asfandyar, Shandana Khan, Cara Mohammed   +4 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

The Neural Mechanisms Underlying the Influence of Pavlovian Cues on Human Decision Making [PDF]

, 2008
In outcome-specific transfer, pavlovian cues that are predictive of specific outcomes bias action choice toward actions associated with those outcomes.
Balleine, Bernard, Bray, Singe, O'Doherty, John P., Rangel, Antonio, Shimojo, Shinsuke   +4 more
core   +2 more sources

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source