Results 81 to 90 of about 12,638,942 (268)

Acute care of severely frail elderly patients in a CGA-unit is associated with less functional decline than conventional acute care

Clinical Interventions in Aging, 2017
Niklas Ekerstad,1,2 Synneve Dahlin Ivanoff,3 Sten Landahl,4 Göran Östberg,5 Maria Johansson,5 David Andersson,6 Magnus Husberg,2 Jenny Alwin,2 Björn W Karlson7 1Department of Cardiology, NU (NÄL-Uddevalla) Hospital Group, Trollhä
Ekerstad N, Dahlin Ivanoff S, Landahl S, Östberg G, Johansson M, Andersson D, Husberg M, Alwin J, Karlson BW   +8 more
doaj  

Hydroxyapatite ceramic-coated femoral components in younger patients followed up for 27 to 32 years: an update of a previous report

Bone & Joint Open
Aims: This study reports the results of 38 total hip arthroplasties (THAs) in 33 patients aged less than 50 years, using the JRI Furlong hydroxyapatite ceramic (HAC)-coated femoral component.
Piyush K. Upadhyay, Nirav Shah, Vishal Kumar, Saqeb B. Mirza   +3 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Usefulness of the WAIS‐IV Short Form for Measuring Cognitive Function in Patients With Schizophrenia

Neuropsychopharmacology Reports
Schizophrenia causes cognitive dysfunction. The assessment of cognitive function is important in the treatment of schizophrenia. The Wechsler Adult Intelligence Scale (WAIS) is used to assess cognitive function in patients with psychiatric disorders. For
Satsuki Ito, Chika Sumiyoshi, Junya Matsumoto, Kenichiro Miura, Yuka Yasuda, Naomi Hasegawa, Harumasa Takano, Tomiki Sumiyoshi, Ryota Hashimoto   +8 more
doaj   +1 more source

OPerative versus non-opERAtive management of isolated ULNAr diaphyseal fractures (OPERA-Ulna): protocol for a randomized controlled trial

Bone & Joint Open
Aims: Isolated fractures of the ulnar diaphysis are uncommon, occurring at a rate of 0.02 to 0.04 per 1,000 cases. Despite their infrequency, these fractures commonly give rise to complications, such as nonunion, limited forearm pronation and supination,
Prism Schneider, Sohail Bajammal, Ross Leighton, Kelcie Witges, Kimberly Rondeau, Paul Duffy   +5 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Does kinesiophobia affect the early functional outcomes following total knee arthroplasty?

Physiotherapy Theory and Practice, 2017
The purpose of this study was to investigate the effects of kinesiophobia on early functional outcomes in patients following total knee arthroplasty (TKA) and how kinesiophobia is related to functional outcomes and pain. The Tampa Scale for Kinesiophobia
Hande Güney-Deniz, Gizem Irem Kınıklı, Ömür Çağlar, B. Atilla, İnci Yüksel   +4 more
semanticscholar   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source