Results 111 to 120 of about 1,032,845 (272)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Frontiers in Sports and Active LivingBackgroundWushu Changbing PiJi is a representative striking action in Wushu long-weapon routines, with its most iconic form derived from the Ma's Tongbei Wushu school, whose staff techniques represent a direct lineage of the Ming Dynasty Shaolin staff ...
Pengfei Zheng +7 more
doaj +1 more source
Search for Evergreens in Science: A Functional Data Analysis
, 2017 Evergreens in science are papers that display a continual rise in annual citations without decline, at least within a sufficiently long time period. Aiming to better understand evergreens in particular and patterns of citation trajectory in general, this
Mei, Yajun, Wang, Jian, Zhang, Ruizhi
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Rainbow plots, Bagplots and Boxplots for Functional Data [PDF]
We propose new tools for visualizing large numbers of functional data in the form of smooth curves or surfaces. The proposed tools include functional versions of the bagplot and boxplot, and make use of the first two robust principal component scores ...
Han Lin Shang, Rob J. Hyndman
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
BMC Complementary and Alternative Medicine, 2019 Background The present study was carried out to prepare multi-herbal combination via comparing antioxidant activity and polyphenolic composition of five medicinal plant extracts of Punica granatum L., Putranjiva roxburghii Wall., Swertia chirata Buch ...
Pardeep Kaur +4 more
doaj +1 more source
On Weighted Multivariate Sign Functions
, 2020 Multivariate sign functions are often used for robust estimation and inference. We propose using data dependent weights in association with such functions.
Chatterjee, Snigdhansu +1 more
core
Screening and metamodeling of computer experiments with functional outputs. Application to thermal-hydraulic computations [PDF]
, 2011 To perform uncertainty, sensitivity or optimization analysis on scalar variables calculated by a cpu time expensive computer code, a widely accepted methodology consists in first identifying the most influential uncertain inputs (by screening techniques),
Auder, Benjamin +3 more
core +2 more sources