Results 91 to 100 of about 300,116 (259)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Principal Component Analysis applied to digital image compression [PDF]
Einstein (São Paulo), 2012 Objective: To describe the use of a statistical tool (Principal ComponentAnalysis – PCA) for the recognition of patterns and compression,applying these concepts to digital images used in Medicine.Methods: The description of Principal Component Analysis ...
Rafael do Espírito Santo
doaj +2 more sources
Basis representation for nuclear densities from principal component analysis
Physics Letters BWe develop an efficient method to represent nuclear densities using basis functions extracted via Principal Component Analysis (PCA). Applying PCA to densities of 75 nuclei calculated with the relativistic continuum Hartree-Bogoliubov (RCHB) theory ...
Chen-Jun Lv +4 more
doaj +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Annales Kinesiologiae, 2019 The purpose of this overview is to present the evidence that adherence to Mediterranean lifestyle components is beneficial for functional and cognitive health.
Cécil J. W. Meulenberg
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
METHOD OF CONSTRUCTION OF GENETIC DATA CLUSTERS
Informatika, 2016 The paper presents a method of construction of genetic data clusters (functional modules) using the randomized matrices. To build the functional modules the selection and analysis of the eigenvalues of the gene profiles correlation matrix is performed ...
N. A. Novoselova, I. E. Tom
doaj
Shipin gongye ke-jiWalnuts are rich in various functional components, and proper roasting can help change the composition and content of functional components. However, there are few studies on the effects of roasting on the endogenous functional components and antioxidant
Mengyang WANG +6 more
doaj +1 more source