Results 131 to 140 of about 1,002,594 (295)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Kinematic and Kinetic Gait Principal Component Domains in Older Adults With and Without Functional Disability: A Cross-Sectional Study

Journal of Functional Morphology and Kinesiology
Objectives: Gait kinematic and kinetic changes have been identified in older adults, highlighting the need to explore the principal age-related components and how these are associated with functional disability.
Juliana Moreira, Bruno Cunha, José Félix, Rubim Santos, Andreia S. P. Sousa   +4 more
doaj   +1 more source

EFFECT OF HOT-WATER BLANCHING IN TREHALOSE SOLUTIONS ON BOTH NUTRITIONAL AND TECHNOLOGICAL QUALITY OF SLICED ORGANIC CARROTS [PDF]

, 2018
The aim of the present work was to evaluate the effect of blanching treatments at 75 and 90°C for 3 min in trehalose solution (4% w/v) on nutritional and technological quality of organic carrot (cv. Romance) slices of 5-mm thickness.
Giordana, Ventriglia, Riccardo, Massantini, Roberto, Moscetti   +2 more
core  

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Dynamic functional principal components [PDF]

, 2012
In this paper, we address the problem of dimension reduction for sequentially observed functional data (X_k : k ∈ Z). Such functional time series arise frequently, e.g., when a continuous time process is segmented into some smaller natural units, such
Hallin, Marc, Hörmann, Siegfried, Kidzinski, Lukasz   +2 more
core  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Fast Bayesian Functional Principal Components Analysis

21 pages, 7 figures, 1 ...
Sartini, Joseph, Zhou, Xinkai, Selvin, Liz, Zeger, Scott, Crainiceanu, Ciprian   +4 more
openaire   +2 more sources

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Generalized Conditional Functional Principal Component Analysis

We propose generalized conditional functional principal components analysis (GC-FPCA) for the joint modeling of the fixed and random effects of non-Gaussian functional outcomes. The method scales up to very large functional data sets by estimating the principal components of the covariance matrix on the linear predictor scale conditional on the fixed ...
Lu, Yu, Zhou, Xinkai, Cui, Erjia, Rogers, Dustin, Crainiceanu, Ciprian M., Wrobel, Julia, Leroux, Andrew   +6 more
openaire   +2 more sources

Robust forecasting of mortality and fertility rates: a functional data approach [PDF]

We propose a new method for forecasting age-specific mortality and fertility rates observed over time. Our approach allows for smooth functions of age, is robust for outlying years due to wars and epidemics, and provides a modelling framework that is ...
Md. Shahid Ullah, Rob J. Hyndman
core