Results 181 to 190 of about 1,002,594 (295)

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Data-driven frailty and reserve phenotypes in older outpatients: a cluster analysis of complementary geriatric assessment. [PDF]

Front Aging
Belfiori M, Salis F, Puxeddu B, Mulas M, Puligheddu M, Mandas A.   +5 more
europepmc   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Comparative Fluctuating Asymmetry and Directional Asymmetry in Four Cattle Skulls. [PDF]

Vet Med Sci
Manuta N, Januzi V, Ozkan E, Ünal B, Çakar B, İşbilir F, Melnyk OP, Güzel BC.   +7 more
europepmc   +1 more source

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

Dimensions of Self-Perceived Functionality in Older Adults Based on the Brazilian National Health Survey. [PDF]

Int J Environ Res Public Health
Nascimento JASD, Guedes TSR, Assis SJC, Souza CG, Souza MC, Cavalcanti RL, Silva KED, Araujo DN, Lopes JM, Guedes MBOG.   +9 more
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Functional connectivity patterns in preschool children associated with working memory performance and digital device use. [PDF]

Sci Rep
Sutormina NV, Kalabina IA, Efimova VL, Nikolaeva EI.   +3 more
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Methylphenidate reorganizes cortical hierarchy through dopaminergic modulation. [PDF]

Nat Commun
Tomasi D, Manza P, Demiral ŞB, Yan W, Miller KB, Veenker F, Zhao J, Lildharrie C, Yonga MV, Abey S, VanDine M, Wang GJ, Volkow ND.   +12 more
europepmc   +1 more source