A Novel Longitudinal Proteomic Aging Index Predicts Mortality, Multimorbidity, and Frailty in Older Adults. [PDF]
Aging CellWe used proteomic data from three longitudinal visits in the ARIC study to construct a single longitudinal proteomic aging index (LPAI) that captures both cumulative aging burden and dynamic aging trajectories. Higher LPAI was associated with increased risks of mortality, frailty, and multimorbidity.
Rao Z +14 more
europepmc +2 more sources
Phenological Variation and Evolution Across Space and Time in the Scarlet Monkeyflower (<i>Erythranthe cardinalis</i>). [PDF]
Ecol EvolClimate change is altering ecological dynamics, particularly in species with latitudinal range variation. This study investigates how the scarlet monkeyflower's flowering phenology has evolved in response to recent droughts in California. We find that southern populations are flowering later and larger, while northern populations flower earlier and ...
Waits J +5 more
europepmc +2 more sources
Tutorial on Bayesian Functional Regression Using Stan. [PDF]
Stat MedABSTRACT This manuscript provides step‐by‐step instructions for implementing Bayesian functional regression models using Stan. Extensive simulations indicate that the inferential performance of the methods is comparable to that of state‐of‐the‐art frequentist approaches.
Jiang Z, Crainiceanu C, Cui E.
europepmc +2 more sources
BMC Medical Research Methodology, 2016 Background Wastewater-based epidemiology (WBE) is a novel approach in drug use epidemiology which aims to monitor the extent of use of various drugs in a community.
Stefania Salvatore +2 more
doaj +1 more source
Application and interpretation of functional data analysis techniques to differential scanning calorimetry data from lupus patients. [PDF]
PLoS ONE, 2017 DSC is used to determine thermally-induced conformational changes of biomolecules within a blood plasma sample. Recent research has indicated that DSC curves (or thermograms) may have different characteristics based on disease status and, thus, may be ...
Sarah K Kendrick +3 more
doaj +1 more source
Characterizing bidirectional transitions in mild cognitive impairment and post-reversion based on longitudinal neuroimaging and cognitive assessments. [PDF]
Alzheimers DementAbstract INTRODUCTION Characterizing transitions of cognitive state, including reversion from mild cognitive impairment (MCI) to normal cognition (NC) and subsequent cognitive stability or deterioration for post‐reversion, has so far remained limited. METHODS Using a retrospective cohort of subjects with an MCI diagnosis at study entry and at least two
Qin Y +8 more
europepmc +2 more sources
Properties of Design-Based Functional Principal Components Analysis [PDF]
, 2009 This work aims at performing Functional Principal Components Analysis (FPCA) with Horvitz-Thompson estimators when the observations are curves collected with survey sampling techniques.
Benko +37 more
core +3 more sources
Looking for Synergies in Healthy Upper Limb Motion: A Focus on the Wrist
IEEE Transactions on Neural Systems and Rehabilitation Engineering, 2023 Recent studies on human upper limb motion highlighted the benefit of dimensionality reduction techniques to extrapolate informative joint patterns.
F. Masiero +5 more
doaj +1 more source
Functional principal components analysis via penalized rank one approximation [PDF]
, 2008 Two existing approaches to functional principal components analysis (FPCA) are due to Rice and Silverman (1991) and Silverman (1996), both based on maximizing variance but introducing penalization in different ways.
Buja, Andreas +2 more
core +5 more sources
Journal of Medical Internet Research, 2021 BackgroundAnalyzing actigraphy data using standard circadian parametric models and aggregated nonparametric indices may obscure temporal information that may be a hallmark of the circadian impairment in psychiatric disorders.
Difrancesco, Sonia +9 more
doaj +1 more source