Results 141 to 150 of about 11,002,643 (373)

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

open access: yesMolecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita   +1 more
wiley   +1 more source

Language Support for Generic Programming in Object-Oriented Languages: Design Challenges

open access: yesТруды Института системного программирования РАН, 2018
It is generally considered that object-oriented (OO) languages provide weaker support for generic programming (GP) as compared with functional languages such as Haskell or SML. There were several comparative studies which showed this. But many new object-
Julia Belyakova
doaj   +1 more source

Total Functional Programming

open access: yes, 2004
JUCS - Journal of Universal Computer Science Volume Nr.
openaire   +1 more source

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

open access: yesMolecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi   +5 more
wiley   +1 more source

A Metamodel of Unit Testing for Object-Oriented Programming Languages [PDF]

open access: yesarXiv, 2009
A unit test is a method for verifying the accuracy and the proper functioning of a portion of a program. This work consists to study the relation and the approaches to test Object-Oriented Programming (OOP) programs and to propose a metamodel that enables the programmer to write the tests while writing the source code to be tested by exploiting the key
arxiv  

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas   +15 more
wiley   +1 more source

Functional Programming Using the New C++ Standard

open access: yesJournal of Economic Development, Environment and People, 2015
Today software technology evolves very quickly, to an old paradigm, called functional programming. This paradigm uses lambda functions ready to be used where declared instead of function pointers.
Radu Bucea-Manea-Tonis   +1 more
doaj  

Performance Evaluation of a Hybrid Programming Model for RSDFT on T2K Open Supercomputer

open access: yesJournal of Algorithms & Computational Technology, 2011
Non-uniform memory access (NUMA) systems, where each processor has its own memory, have been popular platform in high-end computing. While some early studies had reported that a flat-MPI programming model outperformed an OpenMP/MPI hybrid programming ...
Miwako Tsuji, Mitsuhisa Sato
doaj   +1 more source

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