Results 41 to 50 of about 116,342 (254)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Experimental functional realization of attribute grammar system [PDF]

Computer Science Journal of Moldova, 2002
In this paper we present an experimental functional realization of attribute grammar(AG) system for personal computers. For AG system functioning only Turbo Prolog compiler is required.
I. Attali, K. Chebotar, N. Meergus
doaj  

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Pattern-Based Test Suite Reduction Method for Smart Contracts

Applied Sciences
Testing in the software development process is one of the crucial disciplines. The immutability of deployed smart contracts makes tests particularly important in their design and implementation.
Tomasz Górski
doaj   +1 more source

Efficient Procedure Improving Precision of High Conditioned Matrices in Electronic Circuits Analysis [PDF]

Radioengineering, 2018
In this article, we propose several improvements that could be done to SPICE simulator. The first is based on a functional implementation of device models. The advantages of functional implementation are demonstrated on basic Shichman-Hodges model of MOS
D. Cerny, J. Dobes, S. Banas
doaj  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Functional Data Science for Secondary-School Students

Informatics in Education
CODAP is a widely-used programming environment for secondary school data science. Its direct-manipulation–based design offers many advantages to learners, especially younger students.
Paul Biberstein, Thomas Castleman, Luming Chen, Shriram Krishnamurthi   +3 more
doaj   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

A Brief Overview of the Pawns Programming Language

Software
This paper describes the Pawns programming language, currently under development, which uses several novel features to combine the functional and imperative programming paradigms.
Lee Naish
doaj   +1 more source