Results 61 to 70 of about 116,342 (254)
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
A Scientific Calculator for Exact Real Number Computation Based on LRT, GMP and FC++
Acta Universitaria, 2012 Language for Redundant Test (LRT) is a programming language for exact real number computation. Its lazy evaluation mechanism (also called call-by-need) and its infinite list requirement, make the language appropriate to be implemented in a functional ...
J. A. Hernández +2 more
doaj
Types of mathematical thinking implemented in the learn process of functional programming
Tecnura, 2018 Context: This article presents and analyzes the results of a research carried out in a classroom, in the context of the learning of functional programming at university level in Systems Engineering and Computing program, from the application of the types
Omar Iván Trejos Buriticá
doaj +1 more source
Molecular Oncology, EarlyView.Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande +11 more
wiley +1 more source
Formation of cloud-based learning environment for professional training in programming
CTE Workshop Proceedings, 2014 The article is devoted the question of forming a full functional based on cloud technology to study subjects from programming cycle for specialists in programming. The object of the research – the process applying cloud technologies in learning.
N. A. Kharadzjan
doaj +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
3D Dynamic Programming Approach to Functional Equations with Applications
Journal of Function Spaces, 2020 This article demonstrates the graphical existence of a single fixed point while imposing the contractive condition of Chatterjea type F-contraction on F-metric space (briefly as F-MS). We present two examples that verify the validity of the results given
Awais Asif +4 more
doaj +1 more source
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source