Results 71 to 80 of about 11,002,643 (373)

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

FEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla, Zary Forghany, Jin Ma, Johan G. Hollander, Ruta Nachane, Karoly Szuhai, Pancras C. W. Hogendoorn, Peter ten Dijke, Dipen Shah, David A. Baker   +9 more
wiley   +1 more source

The Saccharomyces cerevisiae amino acid transporter Lyp1 has a broad substrate spectrum

FEBS Letters, EarlyView.
In Saccharomyces cerevisiae, Yeast Amino acid Transporter family members mediate the import of amino acids, ranging from substrate specialists to generalists. Here, we show that the specialist transporter, Lyp1, has a broader substrate spectrum than previously described, with affinity constants spanning from micromolar to millimolar.
Foteini Karapanagioti, Sebastian Obermaier, Dirk J. Slotboom, Bert Poolman   +3 more
wiley   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Transforming Functional Logic Programs into Monadic Functional Programs [PDF]

, 2011
We present a high-level transformation scheme to translate lazy functional logic programs into pure Haskell programs. This transformation is based on a recent proposal to efficiently implement lazy non-deterministic computations in Haskell in a monadic style.
Bernd Braßel, Fabian Reck, Sebastian Fischer, Michael Hanus   +3 more
openaire   +1 more source

Proceedings of the 2020 Scheme and Functional Programming Workshop [PDF]

arXiv, 2021
This report aggregates the papers presented at the twenty-first annual Scheme and Functional Programming Workshop, hosted on August 28th, 2020, online and co-located with the twenty-fifth International Conference on Functional Programming. The Scheme and Functional Programming Workshop is held every year to provide an opportunity for researchers and ...
arxiv  

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

ECOLE: a pedagogical environment for non procedural languages

Journal of Computer Science and Technology, 2007
The work described in this paper is related to three areas in the programming world : logic, functional and object programming. The main objective is essentially pedagogical since it is question here to make a synthesis on non procedural languages.
D. E. Zegour, W. K. Hidouci
doaj  

From Principles to Practice with Class in the First Year [PDF]

Electronic Proceedings in Theoretical Computer Science, 2013
We propose a bridge between functional and object-oriented programming in the first-year curriculum. Traditionally, curricula that begin with functional programming transition to a professional, usually object-oriented, language in the second course ...
Sam Tobin-Hochstadt, David Van Horn
doaj   +1 more source

Bisimilarity as a Theory of Functional Programming [PDF]

Electronic Notes in Theoretical Computer Science, 1995
AbstractMorris-style contextual equivalence — invariance of termination under any context of ground type — is the usual notion of operational equivalence for deterministic functional languages such as FPC (PCF plus sums, products and recursive types). Contextual equivalence is hard to establish directly.
openaire   +2 more sources