Results 121 to 130 of about 1,610,238 (288)
IEEE AccessContext: Agile software development, particularly Scrum, enables teams to manage evolving requirements by emphasizing face-to-face communication and incremental deliveries.
Felipe Ramos +8 more
doaj +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Local large language models to simplify requirement engineering documents in the automotive industry
Production and Manufacturing Research: An Open Access JournalIn automotive engineering, requirements management is crucial for determining the functional and technical qualities of a vehicle and ensuring reproducibility and uniformity throughout the development process.
Yilmaz Uygun, Victor Momodu
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Applying Quantitative Model Checking to Analyze Safety in Reinforcement Learning
IEEE AccessReinforcement learning (RL) is rapidly used in safety-centric applications. However, many studies focus on generating optimal policy that achieves maximum rewards.
Ryeonggu Kwon +4 more
doaj +1 more source
On Non-Functional Requirements
15th IEEE International Requirements Engineering Conference (RE 2007), 2007 Although the term 'non-functional requirement' has been in use for more than 20 years, there is still no consensus in the requirements engineering community what non-functional requirements are and how we should elicit, document, and validate them. On the other hand, there is a unanimous consensus that non-functional requirements are important and can ...
openaire +1 more source
Quantile and probability curves without crossing [PDF]
The most common approach to estimating conditional quantile curves is to fit a curve, typically linear, pointwise for each quantile. Linear functional forms, coupled with pointwise fitting, are used for a number of reasons including parsimony of the ...
Alfred Galichon +2 more
core
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Requirements Elicitation and System Design for a Dyslexia Online Assessment and Assistance
Journal of Computing Research and InnovationIn this paper, we discuss the requirements elicitation for a web-based system that provides a dyslexia early screening test and dyslexia information resources.
Aznoora Osman +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source