Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
康复学报, 2017 Objective:To observe the clinical efficacy of warm acupuncture at Shu and Mu acupoints combined with bladder functional training in the treatment of spasm type of neurogenic bladder after spinal cord injury (SCI).Methods:A total of ninety patients with ...
Shijie HAO, Hongyan BI, Zhenmei GAO
doaj
Pre-extubation functional residual capacity and risk of extubation failure among patients with hypoxemic respiratory failure. [PDF]
Sci Rep, 2020 Chen HC +7 more
europepmc +1 more source
Measurement of Functional Residual Capacity in Rabbits and Children Using an Ultrasonic Flow Meter [PDF]
, 2001 Andreas Schibler, Robert H. Henning
openalex +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Effect of positive end-expiratory pressure on functional residual capacity in two experimental models of acute respiratory distress syndrome. [PDF]
J Int Med Res, 2020 Wang YM +7 more
europepmc +1 more source
EFFECT OF ANTENATAL STEROIDS (AS) ON FUNCTIONAL RESIDUAL CAPACITY AND PULMONARY COMPLIANCE IN TWINS. † 1172 [PDF]
, 1996 S Bowling +3 more
openalex +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
International Journal of COPD, 2011 Panagiota Tzani1, Ernesto Crisafulli2, Gabriele Nicolini3, Marina Aiello1, Alfredo Chetta1, Enrico Maria Clini2, Dario Olivieri1 1Department of Clinical Sciences, University of Parma, Parma, Italy; 2Department of Oncology Haematology and Pulmonary ...
Tzani P +6 more
doaj