Results 111 to 120 of about 197,417 (302)

Accurate Measurement of Functional Residual Capacity and Oxygen Consumption of Patients on Mechanical Ventilation [PDF]

, 1983
Kevin Cooper, Peter A. Boswell
openalex   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Rice bran valorization: Oil extraction via extrusion-SCCO2 processing and development of protein hydrolysates from its residue

Applied Food Research
This study presents a comprehensive approach to rice bran valorization, focusing on enhancing oil extraction and utilizing the residual bran for protein hydrolysate production.
Khanitta Ruttarattanamongkol, Sasivimon Chittrakorn, Worasit Tochampa   +2 more
doaj   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Cardiovascular and Respiratory Adaptations During Pregnancy and Exercise in Pregnancy

Physiologia
During pregnancy, physiological adaptations occur in the respiratory and cardiovascular systems to support the increased metabolic needs of both mother and fetus.
Manuela Filipec, Marinela Jadanec Đurin
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Defatting strategies for chia protein production: effects on physicochemical properties

Future Foods
The growing demand for sustainable plant-based proteins has highlighted chia seeds (Salvia hispanica L.), offering 18–32 % protein content. This study evaluates protein extraction efficiency and functional properties across two types of chia product ...
Simon Dirr, Ozlem Ozmutlu Karslioglu, Elif Gokcen Ates, Mecit H. Oztop   +3 more
doaj   +1 more source

Measurement of Functional Residual Capacity during Mechanical Ventilation by Simultaneous Exchange of Two Insoluble Gases [PDF]

, 1981
G Ozanne, Steven E. Zinn, H. Barrie Fairley   +2 more
openalex   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Assessment of functional diversities in patients with Asthma, COPD, Asthma-COPD overlap, and Cystic Fibrosis (CF).

PLoS ONE
The objectives of the present study were to evaluate the discriminating power of spirometric and plethysmographic lung function parameters to differenciate the diagnosis of asthma, ACO, COPD, and to define functional characteristics for more precise ...
Richard Kraemer, Florent Baty, Hans-Jürgen Smith, Stefan Minder, Sabina Gallati, Martin H Brutsche, Heinrich Matthys   +6 more
doaj   +1 more source