Results 41 to 50 of about 197,417 (302)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Comparison of lung volumes measured with computed tomography and whole-body plethysmography – a systematic review

European Clinical Respiratory Journal
Introduction Whole-body plethysmography is the preferred method for measuring the static lung volumes: total lung capacity (TLC), functional residual capacity (FRC) and residual volume (RV), as it also incorporates trapped gas – a common finding in ...
Høgni Janus Bjarnason Olsen, Jann Mortensen   +1 more
doaj   +1 more source

Alterações na capacidade funcional de pacientes após dois anos da cirurgia de revascularização do miocárdio Changes in functional capacity of patients two years after coronary artery bypass grafting surgery

Brazilian Journal of Cardiovascular Surgery, 2010
OBJETIVO: Verificar alterações na capacidade funcional dos pacientes que se submetem à cirurgia de revascularização do miocárdio (CRM) por meio do teste de caminhada de seis minutos (TC6) no seguimento de dois anos. MÉTODOS: Estudo de coorte prospectivo,
Rosane Maria Nery, Marcio Roberto Martini, Cristiane da Rocha Vidor, Mahmud Ismail Mahmud, Maurice Zanini, Aderson Loureiro, Juarez Neuhaus Barbisan   +6 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Volume-controlled inverse ratio ventilation improves safe apnea time in obese patients during the induction of general anesthesia: a randomized controlled trial

Frontiers in Medicine
BackgroundInverse ratio ventilation theoretically increases oxygenation in obese patients. However, it is unknown whether the use of inverse ratio ventilation prolongs the safe apnea time during the induction of anesthesia.
Yonghai Zhang, Bin Li, Chang Xu, Yan Wu, Ling Ma, Fan Yang, Hanxiang Ma, Xinli Ni   +7 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Effect of apparatus on functional residual capacity

British Journal of Anaesthesia, 1996
As the route of breathing and use of airway apparatus such as mask, mouthpiece and noseclip can alter breathing pattern, this study has used the helium dilution method to estimate the effects of mouthpiece and mask breathing on functional residual capacity (FRC) in the supine position, and the change in FRC that occurs between the sitting and supine ...
openaire   +2 more sources

NORMALIZING FUNCTIONAL RESIDUAL CAPACITY (FRC) IN RDS [PDF]

Pediatric Research, 1984
PEEP is used in infants with RDS to counter atelectasis and maintain FRC. FRC is controlled by PEEP yet blood gases, not FRC, are the bases for selecting ventilator settings. To test the hypothesis that maintenance of normal FRC leads to improved pulmonary function and reduced mortality, six paired twin lambs delivered prematurely (125-132 days, term ...
P Richardson, C Bose, F Gonzalez, G King, N Shaw, J Carlstrom   +5 more
openaire   +1 more source