Results 171 to 180 of about 687,881 (263)

Evolutionary Stability of the Shark Snout: Geometric Morphometrics of Ventral Facial Openings. [PDF]

Ann N Y Acad Sci
Aicardi S, Rosa G, Longo A, Bozzo M, Risso B, Damonte E, Amaroli A, Candiani S, Ferrando S.   +8 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Optical coherence tomography enables optical biopsy of endometrial tissue for early cancer detection. [PDF]

Npj Imaging
Thakur S, Lin Y, Xu J, Nie H, Badwan S, Wang L, Sanders BE, Thaker PH, Hagemann AR, McCourt CK, Khabele DM, Powell MA, Mutch DG, Kuroki LM, Hagemann IS, Zhu Q.   +15 more
europepmc   +1 more source

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

Molecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard, Flavie Bénard, Eva Billat, Margaux Le Guyon, Victoria Maltret, Laura Merlet, Chloé Astrid Walter, Tony Avril, Eric Chevet   +8 more
wiley   +1 more source

Stimuli-responsive 4D-bioprinted constructs for musculoskeletal tissue regeneration: Shape-morphing mechanisms, cell-laden bioink engineering, and preclinical outcomes. [PDF]

Regen Ther
Mohammad SI, Vasudevan A, Chohan JS, Salman AF, Singh M, Singh R, Bains PS, Abdulkhakimov P, Astaneh ME, Fereydouni N.   +9 more
europepmc   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

A Novel Radiomics-Integrated Panel for Preoperative Stratification of Pancreatic Neuroendocrine Tumors (PNETs). [PDF]

Cancers (Basel)
Attia A, Hamm J, AbdAlnaeem MA, Ding Z, O'Rorke M, Dillon J, Maluccio M, Skill N, Limbach K.   +8 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

CsmR controls both, motility and cell shape, in Haloferax volcanii. [PDF]

PLoS Genet
Nußbaum P, Grünberger F, Neuschütz F, Chou K, Sivabalasarma S, Eulitz A, Sailer AL, Vogl K, Exterkate M, He W, Marchfelder A, Grohmann D, Albers SV.   +12 more
europepmc   +1 more source