Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Predictive Modeling of Functional and Physical Properties of Extrusion Cooked Ready-To-Eat Corn Meal
Cornmeal is the product of corn-based food processed or pre-cooked through extrusion to produce a ready-to-eat breakfast. The quality of the meal depends on the extrusion cooking factors and process variables.
Adeyemi Adio Aderele +3 more
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
ANALYSIS OF THERMAL DECOMPOSITION KINETICS AND THERMAL HAZARD ASSESSMENT OF NITROBENZOIC ACID ISOMERS BY DSC AND THERMOGRAVIMETRIC METHOD [PDF]
Nitroaromatic acids, ubiquitous intermediates in nitro compounds, find broad applications in pharmaceuticals and fine chemical industries, yet their safety often receives inadequate attention.
Xin Yi Li +4 more
doaj +1 more source
Household consumption of electricity : an estimation of the price and income elasticity for pre-paid users in South Africa [PDF]
Includes bibliographical references (leaves 31-33)
Anderson, Paul
core
This study addressed the problem of evaluating the effectiveness of two protocols of physiotherapy for functional recovery after stroke. In particular, the study explored the use of Functional Principal Component Analysis (FPCA), a multivariate data ...
M. Sánchez-Sánchez +7 more
semanticscholar +1 more source
The role of histone modifications in transcription regulation upon DNA damage
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
This paper concentrates on nonparametrically estimating the conditional density function and conditional mode within the single functional index model for independent data, particularly when the variable of interest is affected by randomly missing data ...
Anis Allal, Abdessamad Dib, Abbes Rabhi
doaj
Boundary String Field Theory of the DDbar System
We develop the boundary string field theory approach to tachyon condensation on the DDbar system. Particular attention is paid to the gauge fields, which combine with the tachyons in a natural way. We derive the RR-couplings of the system and express the
A. A. Gerasimov +49 more
core +3 more sources
Function‐driven design of a surrogate interleukin‐2 receptor ligand
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source

