Results 171 to 180 of about 34,890 (203)

Psychocutaneous Disorders in Pediatric and Adolescent Populations: A Narrative Review. [PDF]

Am J Clin Dermatol
Tan IJ, Mitelman A, Jafferany M.
europepmc   +1 more source

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, EarlyView.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

Monoallelic BRCA1/2 variants in pediatric, adolescent, and young adult patients with central nervous system tumors. [PDF]

ESMO Open
Cipri S, Agolini E, Baldo GD, Cacchione A, Megaro G, Rossi S, Barresi S, Carai A, Colafati GS, Boccuto L, Mastronuzzi A.   +10 more
europepmc   +1 more source

Spatiotemporal Multi‐Omic Mapping Reveals Liver‐Muscle Metabolic Crosstalk in Cancer Cachexia

Advanced Science, EarlyView.
The interactive CCAtlas platform delineates cross‐species, spatiotemporal, and sex‐specific molecular dynamics and metabolic rewiring across organs during cancer cachexia. Hepatic Gamt downregulation curtails hepatic creatine synthesis to trigger systemic creatine insufficiency and consequent skeletal muscle atrophy in LLC tumour‐bearing mice ...
Zihan Tian, Qianyu Wang, Wenyan Gao, Xianfeng Li, Jiawen Fan, Xiaoliang Wu, Siqi Liu, Xiangdong Ming, Danna Yeerken, Mutian Shen, Qingjie Min, Qimin Zhan, Yan Wang   +12 more
wiley   +1 more source

CAR‐Engineered Cell Therapies Beyond Cancer: Reprogramming Fibrosis and Immune‐Mediated Inflammation

Advanced Science, EarlyView.
CAR‐engineered cell therapies are expanding beyond cancer toward immune resetting, pathological‐cell clearance, matrix remodeling, and microenvironmental reprogramming in autoimmune, inflammatory, and fibrotic diseases. This Review compares CAR‐T, CAR‐macrophage, and CAR‐NK platforms and proposes controllable spatiotemporal reprogramming to align ...
Peng Jun Xu, Zhou Jing Zhang, Jing Jin, Hai Yuan Xu, Ya Xin Gu, Qian Qian Yang, You Lang Zhou   +6 more
wiley   +1 more source

In a nutshell: Pandora's Box-B-cell lymphoproliferation masking inborn errors of immunity. [PDF]

Br J Haematol
Sánchez-Ramón S, Bussel JB.
europepmc   +1 more source

D4F‐Functionalized Ceria Nanozyme‐CasRx Platform Suppresses STING and Reprograms the Renal Immune Niche in Acute Kidney Injury

Advanced Science, EarlyView.
D4F‐functionalized ceria nanozyme–CasRx nanoparticles preferentially target renal macrophages through SR‐B1‐mediated uptake in ischemia–reperfusion injury. Ceria scavenges excessive ROS, while CasRx silences STING signaling, shifting macrophages toward a less inflammatory, pro‐resolving state and increasing the proportion of regulatory T cells.
Weibo Chen, Ming Li, Xuesheng Wang, Jiajia Sun, Ziyuan Zhang, Yongfeng Gong, Benkang Shi, Nengwang Yu, Yunuo Mao, Shengtian Zhao, Xiulin Zhang, Liqiang Guo   +11 more
wiley   +1 more source

Epilepsy, Cognitive, and Behavioral Outcomes in Neurocutaneous Syndromes: A Comparative Review of NF1, TSC, and Sturge-Weber Syndrome. [PDF]

Children (Basel)
Jurca AA, Vulturar R, Chis A, Trandafir AL, Petchesi CD, Kozma K, Severin E, Hodisan R, Jurca CM, Vicas SI, Jurca SI, Jurca AD.   +11 more
europepmc   +1 more source

Germline DDX41 mutations in myeloid neoplasms: a comprehensive review. [PDF]

Korean J Intern Med
Lee JH, Hur EH, Cho YU.
europepmc   +1 more source

The metastatic spectrum in functional and non-functional NENs: mechanistic insights from multi-omics. [PDF]

Front Endocrinol (Lausanne)
Wang Z, Ji X, Wang Z, Zheng S, Liu F, Lu J, Chang H.   +6 more
europepmc   +1 more source