Results 171 to 180 of about 140,548 (311)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

The Effect of Leadership Style on Turnover Intention of Salespeople: Incentive System as Moderating Variable

, 2011
[[abstract]]For most enterprises and organizations, the salespeople are responsible for developing new customer, maintaining good communication and relationship with existing customers, as well as keeping updated of the changing industry environment ...
Chou Pei-Chi
core  

Research and implementation of intelligent clothing personalized customization system based on deep learning. [PDF]

Sci Rep
Lu Y.
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Asymmetric Osteotomies in Structural Rhinoplasty: A Pisa Tower-Inspired Approach for Crooked Noses. [PDF]

Aesthet Surg J Open Forum
Bianco N, Varricchio A, De Cicco D, Cavaliere A, Lizambri D, D'Antonio S.   +5 more
europepmc   +1 more source

Contemporary style with functionality [PDF]

British Dental Journal, 2010
openaire   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Investigating the effect of depression, stress, and attachment style on leftward cradling bias.

, 2013
The majority of women cradle infants to the left of their midline ? this phenomenon is known as leftward cradling bias. The right hemisphere's specialization for emotional processing is believed to explain the bias as it would facilitate emotional ...
McGrath, Margaret J
core  

Effect of device and expiratory maneuver technique on peak expiratory flow measurements. [PDF]

Clin Physiol Funct Imaging
Csonka LL, Tikkakoski A, Karjalainen J, Lehtimäki L.   +3 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source