Results 111 to 120 of about 3,186,814 (251)

EP300‐Mediated MTF1‐K218 Lactylation Buffers AR‐Driven Copper Overload to Suppress Cuproptosis in Castration‐Resistant Prostate Cancer

Advanced Science, EarlyView.
Androgen receptor (AR) drives copper accumulation in prostate cancer while inducing MTF1 to buffer copper toxicity. EP300‐mediated lactylation of MTF1 at K218 promotes its nuclear translocation and metallothionein expression, sequestering cytosolic copper and preventing mitochondrial cuproptosis.
Kai Li, Yong Wei, Yongshan Li, Yuxiang Dong, Jiancheng Lv, Mingzhi Yuan, Ao Shen, Fuyang Liu, Yetao Zhang, Youjian Li, Ruixi Yu, Yang Liu, Tong Zhao, Jun Wang, Kai Zhou, Zongyao Fan, Manning Wang, Jun Xu, Mulong Du, Min Gu, Bing Yao, Qingyi Zhu   +21 more
wiley   +1 more source

Knowledge and Attitude of European Urology Residents About Ionizing Radiation

, 2013
OBJECTIVE To evaluate the attitude and knowledge of urology residents concerning ionizing radiation, we undertook a survey of European urology residents.
Silay, Mesrur Selcuk, Soylemez, Haluk, Sancaktutar, Ahmet Ali, Altunoluk, Bulent, Atar, Murat, Penbegül, Necmettin, Bozkurt, Yasar   +6 more
core   +1 more source

USP30‐Mediated Deubiquitination of PEX5 Suppresses Pexophagy to Drive Tubular Injury in Diabetic Kidney Disease

Advanced Science, EarlyView.
USP30 accumulation in diabetic renal tubular epithelial cells deubiquitinates PEX5, suppresses pexophagy, and drives dysfunctional peroxisome accumulation and tubular injury. USP30 depletion restores PEX5 ubiquitination and pexophagy, improves peroxisomal function, and alleviates tubular damage, highlighting USP30 as a therapeutic target in diabetic ...
Jia Li, Chaoyang Hua, Guangpu Li, Furong Zhai, Jingjing Ren, Shaokang Pan, Qi Feng, Jianguo Wen, Dongwei Liu, Zhangsuo Liu, Jiayu Duan   +10 more
wiley   +1 more source

Female LUTS adaptations to COVID era: Lessons learned from the ICS TURNOVER (Transition of fUnctional uRology to New COVID ERa). [PDF]

Continence (Amst), 2022
López-Fando L, Calleja Hermosa P, Hajebrahimi S, Plata M, Padilla Fernández B, Cruz F, Hashim H, Arlandis S.   +7 more
europepmc   +1 more source

An Intravesical Akkermansia muciniphila‐Based Chemo‐Immunotherapeutic Platform for Bladder Cancer

Advanced Science, EarlyView.
Pasteurized Akkermansia muciniphila is engineered into an intravesical F127/doxorubicin platform that couples localized chemotherapy with immune remodeling. By inducing apoptosis, ferroptosis, and immunogenic cell death, this chemo‐immunotherapeutic system enhances dendritic‐cell maturation, antigen cross‐presentation, and tumor‐specific CD8+ T‐cell ...
Rongkang Li, Anguo Zhao, Qi Zhuang, Lei Peng, Rui Liang, Jiadong Zhao, Yang Liu, Dashi Deng, Peng Yu, Xiqi Peng, Shaohua Zhang, Song Wu   +11 more
wiley   +1 more source

Evolution of Quality of Life and Treatment Adherence after One Year of Intermittent Bladder Catheterisation in Functional Urology Unit Patients. [PDF]

J Clin Med, 2023
Fernandez-Lasquetty Blanc B, Hernández Martínez A, Lorenzo García C, Baixauli Puig M, Estudillo González F, Martin Bermejo MV, Ortega Checa MA, Alcaraz Zomeño E, Torres Bacete A, Ferrández Franco G, Benito Santos B, Fernández Llorente G, Guerrero Andrádes MC, Rodríguez Diaz M, Louis Lauture MP, Jiménez Mayorga I, Serrano-Abiétar R, Garrido Mora MA, Barcia Barrera F, Asensio Malo G, Morcillo Marín M, Lluesma Martinez V, Valero Escribá ML, Tendero Ruiz S, Romay Cea RA, Marín Valero M, Rodríguez-Almagro J.   +26 more
europepmc   +1 more source

Achieving sustainability in urology:a consensus study by the European association of urology (EAU) section office

PURPOSE: To assess the awareness, attitudes, and practices related to environmental sustainability among urologists and to explore targeted interventions, educational initiatives to enhance sustainability in urological practice while maintaining high ...
Güven, Selçuk, Ralph, David, Akgül, Burak, Finazzi Agro, Enrico, Bettocchi, Carlo, Soytürk, Selim, Sönmez, Mehmet Giray, Sanguedolce, Francesco, Herrmann, Thomas R. W., Roupret, Morgan, Gadzhiev, Nariman, Vasquez, Juan Luis, Mallet, Richard, Aydın, Abdullatif, Rassweiler, Jens, Knoll, Thomas, Keller, Etienne Xavier, Ahmed, Kamran, Tozsin, Atınç, Colecchia, Maurizio, Musquera, Mireia, Omar, Muhammad Imran, Traxer, Olivier, Dasgupta, Prokar, Arslan, Erkan, Pradere, Benjamin, Çakır, Ömer Onur, Tunç, Lütfi, Herrmann, Thomas R W, Sılay, Selçuk Mesrur   +29 more
core   +1 more source

Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos

Advanced Science, EarlyView.
ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou, Ruixi Yu, Xuan Zhou, Feng Shi, Zeyu Lin, Peng Gao, Lujia Wang, Ninghan Feng, Zhong Wu, Dawei Wang   +9 more
wiley   +1 more source

De-obstruction of bladder outlet in humans reverses organ remodelling by normalizing the expression of key transcription factors

BMC Urology
Background Benign prostatic hyperplasia in elderly males often causes bladder outlet obstruction termed benign prostatic obstruction (BPO). BPO induces lower urinary tract symptoms and quantifiable urodynamic alterations in bladder function.
Akshay Akshay, Ali Hashemi Gheinani, Mustafa Besic, Sophie Braga, Anne-Christine Uldry, Manfred Heller, Hubert Rehrauer, Catharine Aquino Fournier, Fiona C. Burkhard, Katia Monastyrskaya   +9 more
doaj   +1 more source

Proximal Urethrostomy Versus Urethroplasty for Complex Urethral Strictures

European Urology Open Science
Background: The optimal treatment for complex urethral stricture (CUS) is yet to be determined. Comparisons of methods based on validated questionnaires or objective outcome measures are lacking.
Nir J. Rahav, Mohamad Udah, Sarit Cohen, Tali Bdolah-Abram, Boris Chertin, Ofer Z. Shenfeld   +5 more
doaj   +1 more source