Results 151 to 160 of about 6,284,740 (249)

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Type-Strain-Anchored Phylogenomics Reveals Taxonomic Discordance and Functional Variation in <i>Agrobacterium</i>. [PDF]

Int J Mol Sci
Filatova MS, Evseev PV, Ignatov AN, Asmaeva PV, Chaplin AV, Miroshnikov KA.   +5 more
europepmc   +1 more source

Functional variation (Q63R) in the cannabinoid CB2 receptor may affect the severity of COVID-19: a human study and molecular docking. [PDF]

Arch Virol, 2021
Rastegar M, Samadizadeh S, Yasaghi M, Moradi A, Tabarraei A, Salimi V, Tahamtan A.   +6 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Functional Variation in the Feeding Apparatus of Charadriiform Shorebirds With Emphasis on Bill-Tip Organs and Micro Tongue Tip Spines. [PDF]

J Morphol
Lin CT, Thomas DB, Battley PF.
europepmc   +1 more source

First variation of functional Wulff shapes

Using an approximation procedure we establish, for suitable perturbations, a weighted functional version of Aleksandrov's variational lemma in the family of convex functions with compact domain. The resulting formula is then applied to evaluate the first
Ulivelli, Jacopo; orcid:
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Editorial: Evolutionary dynamics, functional variation and application of plant organellar genomes. [PDF]

Front Plant Sci
Wu Z, Tembrock LR.
europepmc   +1 more source

Sequence and Functional Variation in the HIV-1 Rev Regulatory Axis. [PDF]

Curr HIV Res, 2020
Jackson PEH, Dzhivhuho G, Rekosh D, Hammarskjold ML.   +3 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source