Results 211 to 220 of about 125,875 (269)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Dispersion, Separation, and Optical Sensing Applications of Single-Walled Carbon Nanotubes. [PDF]

Materials (Basel)
Huang Z, Lu N, Wang L, Wen Y, Liu G, Peng H, Wang L.   +6 more
europepmc   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Aromatization-Driven Borylene Generation from Borepin Precursors Enables Fused Borirane Synthesis and Selective Alkene Functionalization. [PDF]

J Am Chem Soc
Maurya JP, Bushmin D, Church JR, Dey K, Diskin-Posner Y, Avram L, Shimon LJW, Gnaim S.   +7 more
europepmc   +1 more source

Emerging Strategies for <i>meta</i>-Heteroatom Functionalization of Pyridines. [PDF]

JACS Au
Francisco TN, Silva AMS, Albuquerque HMT.   +2 more
europepmc   +1 more source

Sustainable nanomedicine:green synthesis of functional nanomaterials and its applications. [PDF]

Front Chem
Halder B, Satpathy A, Kumari K, Nigam VK.   +3 more
europepmc   +1 more source

Radical enantioconvergent meta-C─H alkylation of pyridines. [PDF]

Sci Adv
Qin S, Gao X, Li Q, Zhang M, Lin Y, Wang M, Yang M, Wang S, Zhou Z, Gao H, Yi W, Zeng Z.   +11 more
europepmc   +1 more source

Transition- Metal-Free Piranha-Assisted One-Pot Oxidative Iodination of Graphene Oxide for Selective Turn-On Fluorescence Sensing of Cu²⁺ Ions. [PDF]

Luminescence
Elavarasan A, Kalaiyarasi M, Tamilarasu K, Rex KGR, Santhamoorthy M, Al-Kahtani AA, Pradhan T, Ramesh P.   +7 more
europepmc   +1 more source